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Receptor, PAR-1

More information in Books or onNLM PubMed
Definition: A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.      Other names Receptor, PAR1; Receptor, PAR 1; Proteinase Activated Receptor 1; Protease Activated Receptor 1; PAR 1 Receptor; Proteinase-Activated Receptor 1; PAR1 Receptor; Protease-Activated Receptor 1; PAR-1 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PAR-1 receptor (1-41), human  0   *Peptide Fragments *Receptor, PAR-1. J Pharmacol Exp Ther 2009 Feb;328(2):378-89
vorapaxar  0   *Lactones *Pyridines Receptors, Thrombin/antagonists & inhibitors Receptor, PAR-1/antagonists & inhibitors. J Med Chem 2008 Jun 12;51(11):3061-4
decahydro-1-methyl-3-oxo-9-(2-(5-(3-fluorophenyl)-2-pyridinyl)ethenyl)furo(3,4-g)isoquinoline-6(3H)-carboxylic acid ethyl ester  0   *Isoquinolines *Pyridines Receptor, PAR-1/antagonists & inhibitors. J Med Chem 2007 Oct 18;50(21):5147-60
mercaptopropionyl-phenylalanyl-cyclohexylalanyl-cyclohexylalanyl-arginyl-lysyl-prolyl-asparaginyl-aspartyl-lysinamide  0   *Oligopeptides Receptor, PAR-1/antagonists & inhibitors. Bull Exp Biol Med 2005 Sep;140(3):285-8
threonyl-phenylalanyl-leucyl-leucyl-arginyl-asparagine  0   *Oligopeptides Receptor, PAR-1/agonists. Bull Exp Biol Med 2005 Sep;140(3):285-8
proatherocytin protein, Proatheris superciliaris  0   *Viper Venoms Receptor, PAR-1/agonists. Toxicon 2005 Oct;46(5):490-9
Ser-Phe-Phe-Leu-Arg-Asn  0   *Oligopeptides Receptor, PAR-1/agonists. Bull Exp Biol Med 2005 Jan;139(1):4-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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