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Sterol O-Acyltransferase

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Definition: An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.      Other names Cholesterol Acyltransferase; Acyl-CoA-Cholesterol Acyltransferase; Sterol O Acyltransferase; O-Acyltransferase, Sterol; Esterifying Enzyme, Cholesterol; Enzyme, Cholesterol Esterifying; Acyltransferase, Cholesterol; Acyltransferase, Acyl-CoA-Cholesterol; Acyl CoA Cholesterol Acyltransferase; Cholesterol Esterifying Enzyme
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ARE2 protein, S cerevisiae  EC 2.3.1.26   *Sterol O-Acyltransferase.
ARE1 protein, S cerevisiae  EC 2.3.1.26   *Sterol O-Acyltransferase *Saccharomyces cerevisiae Proteins.
flavasperone  0   *Chromones Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 2008 Sep;61(9):568-72
SAT1 protein, Arabidopsis  EC 2.3.1.26   *Sterol O-Acyltransferase *Arabidopsis Proteins. Plant Physiol 2007 Nov;145(3):974-84
pactimibe  0   *Indoleacetic Acids Sterol O-Acyltransferase/antagonists & inhibitors. N Engl J Med 2006 Mar 23;354(12):1253-63
sterol O-acyltransferase 1  EC 2.3.1.26   *Sterol O-Acyltransferase. J Lipid Res. 2004 Apr;45(4):686-96
CP 113  0   *Pyridines *Sulfides Sterol O-Acyltransferase/antagonists & inhibitors. J Lipid Res 2004 Feb;45(2):378-86
terpendole E  0   *Diterpenes *Indoles Sterol O-Acyltransferase/antagonists & inhibitors. Chem Biol. 2003 Feb;10(2):131-7
phenylpyropene B  0   *Heterocyclic Compounds with 4 or More Rings Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 2002 Nov;55(11):1004-8
phenylpyropene A  0   *Heterocyclic Compounds with 4 or More Rings Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 2002 Nov;55(11):1004-8
SMP 500  0   *Naphthyridines Urea/*analogs & derivatives Sterol O-Acyltransferase/antagonists & inhibitors. Pharmacology 2002 May;65(1):18-25
phenylpyropene C  0   *Heterocyclic Compounds with 4 or More Rings Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 2002 Feb;55(2):211-4
(N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine)  0   *Cinnamates *Piperazines Sterol O-Acyltransferase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2001 Jul;49(7):830-9
N-(2,6-diethylphenyl)-N'-(3-(2-methylphenyl)-6,7-dihydro-5H-cyclopenta(f)(l)benzothiophen-2-yl)urea  0   *Thiophenes Urea/*analogs & derivatives Sterol O-Acyltransferase/antagonists & inhibitors. Jpn J Pharmacol 2001 Apr;85(4):423-33
sterol O-acyltransferase 2  EC 2.3.1.26   *Sterol O-Acyltransferase. Biochem biophys Res Commun 2001 Mar 30;282(2):580-8
TS 962  0   *Acetamides Sterol O-Acyltransferase/antagonists & inhibitors. Atherosclerosis 1999 Oct;146(2):237-42
N-(2,6-diisopropylphenyl)-4,7,10,13,16,19-docosahexaenamide  0   *Docosahexaenoic Acids Sterol O-Acyltransferase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jul 19;9(14):2039-42
N-(4,5-diphenylthiazol-2-yl)-N'-n-butylurea  0   *Thiazoles Urea/*analogs & derivatives Sterol O-Acyltransferase/antagonists & inhibitors. Pharmazie 1999 Jan;54(1):19-23
N-(4,5-diphenylthiazol-2-yl)-N'-(2,6-bis(2-methylethyl)phenyl)urea  0   *Phenylurea Compounds *Thiazoles Sterol O-Acyltransferase/antagonists & inhibitors. Pharmazie 1999 Jan;54(1):19-23
FR 186485  0   *Pyridines Urea/*analogs & derivatives Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1998 Oct 22;41(22):4408-20
FR 190809  0   *Pyridines Urea/*analogs & derivatives Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1998 Oct 22;41(22):4408-20
FR 186054  0   *Pyrazoles Urea/*analogs & derivatives Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1998 Jun 18;41(13):2390-410
FR 179254  0   *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. Bioorg Med Chem 1998 Jan;6(1):15-30
NTE 122  0   *Aniline Compounds *Cyclohexanes Sterol O-Acyltransferase/antagonists & inhibitors. Biochem Biophys Res Commun 1998 Mar 17;244(2):347-52
alpha-(((2,6-bis(1-methylethyl)phenyl)amino)carbonyl)benzeneacetic acid dodecyl ester  0   *Malonates *Phenylacetates Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1998 Feb 26;41(5):682-90
T 2591  0   *Aniline Compounds *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. Biol Pharm Bull 1997 Oct;20(10):1056-60
2-(5-dodecylisoxazol-3-yl)-2-phenyl-N-(2,4,6-trimethoxyphenyl)acetamide  0   *Acetamides *Isoxazoles Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1996 Sep 27;39(20):3908-19
2-(3-dodecylisoxazol-5-yl)-2-phenyl-N-(2,4,6-trimethoxyphenyl)acetamide  0   *Acetamides *Isoxazoles Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1996 Sep 27;39(20):3908-19
2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide  0   *Tetrazoles Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1996 Jun 7;39(12):2354-66
FR 129169  0   *Acetamides Sterol O-Acyltransferase/antagonists & inhibitors. Jpn J Pharmacol 1996 Jan;70(1):35-41
pyripyropene Q  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase. J Antibiot (Tokyo) 1996 Mar;49(3):292-8
pyripyropene P  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1996 Mar;49(3):292-8
pyripyropene O  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase. J Antibiot (Tokyo) 1996 Mar;49(3):292-8
pyripyropene N  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1996 Mar;49(3):292-8
pyripyropene M  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1996 Mar;49(3):292-8
isochromophilone VIII  0   *Benzopyrans Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1996 Mar;49(3):223-9
isochromophilone VII  0   *Benzopyrans Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1996 Mar;49(3):223-9
FCE 27677  0   *Aniline Compounds *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. J Lipid Res 1996 Jan;37(1):1-14
N-butyl-3-(4-decyloxybenzamido)-4-(methylthio)benzamide  0   *Benzamides Sterol O-Acyltransferase/antagonists & inhibitors. Biochem Pharmacol 1996 Feb 23;51(4):413-21
TEI 6620  0   *Amides *Benzofurans Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1996 Mar 15;39(6):1262
isohalobacillin  0   *Peptides, Cyclic Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Dec;48(12):1419-24
FR 145237  0   *Benzofurans *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. Biochim Biophys Acta 1995 Dec 7;1259(3):254-60
GERI-BP001 B  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Aug;48(8):751-6
GERI-BP001 A  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Aug;48(8):751-6
GERI-BP001 M  0   *Pyridines *Sesquiterpenes Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Aug;48(8):751-6
isochromophilone VI  0   *Benzopyrans Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jul;48(7):696-702
isochromophilone V  0   *Benzopyrans Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jul;48(7):696-702
isochromophilone IV  0   *Benzopyrans Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jul;48(7):696-702
isochromophilone III  0   *Benzopyrans Sterol O-Acyltransferase/antagonists & inhibitors Receptors, Endothelin/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jul;48(7):696-702
447C88  0   *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. J Chromatogr B Biomed Appl 1995 Jan 20;663(2):275-87
FY 087  0   Thioacetamide/*analogs & derivatives Sterol O-Acyltransferase/antagonists & inhibitors. Biochem Pharmacol 1995 Mar 1;49(5):643-51
HL 004  0   *Acetanilides Sterol O-Acyltransferase/antagonists & inhibitors. Life Sci 1995 Jan 6;56(7):509-20
RP 73163  0   *Imidazoles Sterol O-Acyltransferase/antagonists & inhibitors. J Chromatogr B Biomed Appl 1994 Nov 4;661(1):119-31
terpendole D  0   *Diterpenes *Indoles Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jan;48(1):1-4
terpendole C  0   *Diterpenes *Indoles Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jan;48(1):1-4
terpendole B  0   *Diterpenes *Indoles Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jan;48(1):1-4
terpendole A  0   *Diterpenes *Indoles Sterol O-Acyltransferase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jan;48(1):1-4
E 5324  141799-76-0   *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. Atherosclerosis 1994 Jun;107(2):187-201
N-(4-(2-chlorophenyl)-6,7-dimethyl-3-quinolyl)-N'-(2,4-difluorophenyl)urea  128831-46-9   *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1994 Jun 24;37(13):2079-84
N-(2,6-bis(isopropyl)phenyl)-N'-((1-(4-(dimethylaminomethyl)phenyl)cyclopentyl)methyl)urea  133825-80-6   *Phenylurea Compounds Sterol O-Acyltransferase/antagonists & inhibitors. J Med Chem 1994 May 27;37(11):1652-9
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