encyclopedia of medical concepts
ψ
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Prostaglandin-Endoperoxide Synthases
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Definition
: Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
DF: PG SYNTHASE
Examples
Cyclooxygenase 1
;
Cyclooxygenase 2
Other names
Prostaglandin-
Endoperoxide Synthase; Prostaglandin Synthase; Prostaglandin H Synthase; PGH Synthase; Fatty Acid Cyclo-
Oxygenase; Synthetase, Prostaglandin H2; Synthetase, Prostaglandin Endoperoxide; Synthetase, Prostaglandin; Synthetase, PGH2; Synthases, Prostaglandin-
Endoperoxide; Synthase, Prostaglandin-
Endoperoxide; Synthase, Prostaglandin H; Synthase, Prostaglandin G-
H; Synthase, Prostaglandin; Synthase, PGH; Prostaglandin G H Synthase; Prostaglandin Endoperoxide Synthases; Prostaglandin Cyclo Oxygenase; G-
H Synthase, Prostaglandin; Fatty Acid Cyclo Oxygenase
Substance
CAS Registry & name
Categories
Source
Drugs
*
Ptges protein, rat
EC 1.14.99.1
*Prostaglandin-Endoperoxide Synthases.
Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H165-74
2-
hydroxymethyl-
4-
(5-
(4-
methoxyphenyl)-
3-
trifluoromethyl-
1H-
1-
pyrazolyl)-
1-
benzenesulfonamide
0
*Pyrazoles
*Sulfonamides
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Eur J Drug Metab Pharmacokinet 2003 Apr-Jun;2892):137-47
6-
ethoxy-
3-
(4-
methanesulfonylphenyl)-
4-
phenylpyran-
2-
one
0
*Pyrones
*Sulfones
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
J Med Chem 2003 Nov 6;46(23):4872-82
cyclooxygenase-
3
EC 1.14.99.1
*Prostaglandin-Endoperoxide Synthases.
Science 2002 Sep 20;297(5589):1976
7-
methoxy-
alpha-
methyl-
2-
naphthaleneacetic acid
0
Naproxen/*analogs & derivatives
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Planta Med 2000 Jun;66(5):471-3
SC 299
0
*Oxazoles
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Biochemistry 2000 May 23;39(20):6228-34
L 778736
0
*Furans
*Pyridines
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Bioorg Med Chem Lett 1999 Nov 15;9(22):3187-92
FR 122047
130717-51-0 Piperazine, 1-
((4,5-
bis(4-
methoxyphenyl)-
2-
thiazolyl)carbonyl)-
4-
methyl-
, monohydrochloride
*Piperazines
*Thiazoles
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Eur J Pharmacol 1993 Oct 19;243(2):179-84
N-
succinimidyl-
1-
(4-
chlorobenzoyl)-
5-
methoxy-
2-
methyl-
1H-
indole-
3-
acetate
104425-42-5
*Succinimides
Indomethacin/*analogs & derivatives
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Biochemistry 1993 Mar 16;32(10):2710-6
1-
(4-
chlorobenzoyl)-
3-
(2-
(1H-
imidazol-
1-
yl)-
2-
oxoethyl)-
5-
methoxy-
2-
methyl-
1H-
indole
78486-46-1
*Imidazoles
Indomethacin/*analogs & derivatives
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Biochemistry 1993 Mar 16;32(10):2710-6
sinapaldehyde
4206-58-0
Acrolein/*analogs & derivatives
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors.
Planta Med 1992 Feb;58(1):14-8
coniferaldehyde
458-36-6
Acrolein/*analogs & derivatives
Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors
Nitric Oxide Synthase.
Planta Med 1992 Feb;58(1):14-8