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Prostaglandin-Endoperoxide Synthases

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Definition: Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.  DF: PG SYNTHASE   
Examples Cyclooxygenase 1; Cyclooxygenase 2 		Other names Prostaglandin-Endoperoxide Synthase; Prostaglandin Synthase; Prostaglandin H Synthase; PGH Synthase; Fatty Acid Cyclo-Oxygenase; Synthetase, Prostaglandin H2; Synthetase, Prostaglandin Endoperoxide; Synthetase, Prostaglandin; Synthetase, PGH2; Synthases, Prostaglandin-Endoperoxide; Synthase, Prostaglandin-Endoperoxide; Synthase, Prostaglandin H; Synthase, Prostaglandin G-H; Synthase, Prostaglandin; Synthase, PGH; Prostaglandin G H Synthase; Prostaglandin Endoperoxide Synthases; Prostaglandin Cyclo Oxygenase; G-H Synthase, Prostaglandin; Fatty Acid Cyclo Oxygenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ptges protein, rat  EC 1.14.99.1   *Prostaglandin-Endoperoxide Synthases. Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H165-74
2-hydroxymethyl-4-(5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl)-1-benzenesulfonamide  0   *Pyrazoles *Sulfonamides Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Eur J Drug Metab Pharmacokinet 2003 Apr-Jun;2892):137-47
6-ethoxy-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-one  0   *Pyrones *Sulfones Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. J Med Chem 2003 Nov 6;46(23):4872-82
cyclooxygenase-3  EC 1.14.99.1   *Prostaglandin-Endoperoxide Synthases. Science 2002 Sep 20;297(5589):1976
7-methoxy-alpha-methyl-2-naphthaleneacetic acid  0   Naproxen/*analogs & derivatives Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Planta Med 2000 Jun;66(5):471-3
SC 299  0   *Oxazoles Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Biochemistry 2000 May 23;39(20):6228-34
L 778736  0   *Furans *Pyridines Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Nov 15;9(22):3187-92
FR 122047  130717-51-0 Piperazine, 1-((4,5-bis(4-methoxyphenyl)-2-thiazolyl)carbonyl)-4-methyl-, monohydrochloride  *Piperazines *Thiazoles Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Eur J Pharmacol 1993 Oct 19;243(2):179-84
N-succinimidyl-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate  104425-42-5   *Succinimides Indomethacin/*analogs & derivatives Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Biochemistry 1993 Mar 16;32(10):2710-6
1-(4-chlorobenzoyl)-3-(2-(1H-imidazol-1-yl)-2-oxoethyl)-5-methoxy-2-methyl-1H-indole  78486-46-1   *Imidazoles Indomethacin/*analogs & derivatives Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Biochemistry 1993 Mar 16;32(10):2710-6
sinapaldehyde  4206-58-0   Acrolein/*analogs & derivatives Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors. Planta Med 1992 Feb;58(1):14-8
coniferaldehyde  458-36-6   Acrolein/*analogs & derivatives Prostaglandin-Endoperoxide Synthases/antagonists & inhibitors Nitric Oxide Synthase. Planta Med 1992 Feb;58(1):14-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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