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Nitric Oxide Synthase
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Definition
: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
general; prefer specifics
Examples
Nitric Oxide Synthase Type I
;
Nitric Oxide Synthase Type II
;
Nitric Oxide Synthase Type III
Other names
Synthase, Nitric Oxide; Oxide Synthase, Nitric; Nitric Oxide Synthetase; Nitric-
Oxide Synthetase; Nitric-
Oxide Synthase; NO Synthase
Substance
CAS Registry & name
Categories
Source
Drugs
*
NOA1 protein, Arabidopsis
EC 1.14.13.39
*Nitric Oxide Synthase
*Arabidopsis Proteins.
Science 2003 Oct 3;302(5642):100-3
N-
((3-
(aminomethyl)phenyl)methyl)ethanimidamide
0
*Imines
Nitric Oxide Synthase/antagonists & inhibitors.
Microcirculation. 2004 Sep;11(6):503-15
Nostrin protein, mouse
0
*DNA-Binding Proteins
*Adaptor Proteins, Signal Transducing
Nitric Oxide Synthase.
Biochem Biophys Res Commun 2005 Jan 21;326(3):594-9
1-
cyclopropanecarbonyl-
3-
(2-
amino-
5-
methoxyphenyl)-
4,5-
dihydro-
1H-
pyrazole
0
*Aniline Compounds
*Pyrazoles
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 2004 Nov 4;47(23):5641-50
1-
cyclopropanecarbonyl-
3-
(2-
amino-
5-
chlorophenyl)-
4,5-
dihydro-
1H-
pyrazole
0
*Aniline Compounds
*Pyrazoles
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 2004 Nov 4;47(23):5641-50
AR C102222AA
0
*Quinazolines
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 2003 Mar 13;46(6):913-6
N-
(4-
(2-
((3-
chlorophenylmethyl)amino)ethyl)phenyl)-
2-
thiophenecarboxamide
0
*Amidines
*Thiophenes
Nitric Oxide Synthase/antagonists & inhibitors.
Proc Natl Acad Sci U S A 2004 Apr 20; 101(16):5892-7
6-
(4-
(N,N-
dimethylaminoethoxy)-
5,6,7,8-
tetrahydronaphthalen-
1-
yl)pyridin-
2-
ylamine
0
*Aminopyridines
*Tetrahydronaphthalenes
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 2004 Mar 11;47(6):1575-86
5-
fluoro-
N6-
(iminoethyl)lysine
0
Lysine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 2004 Feb 12;47(4):900-6
4-
N-
nitroarginyl-
4-
aminoprolinamide
0
*Dipeptides
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 2004 Jan 29;47(3):703-10
N-
(6-
bromo-
7-
hydroxycoumarin-
4-
yl)methoxycarbonyl-
N-
(3-
(aminomethyl)benzyl)acetamide
0
*Amidines
*Coumarins
Nitric Oxide Synthase/antagonists & inhibitors.
Bioorg Med Chem 2002 Jun;10(6):1919-27
NOSTRIN protein, human
0
*Intracellular Signaling Peptides and Proteins
Nitric Oxide Synthase.
Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17167-72
PPA 250
0
*Imidazoles
*Pyridines
Nitric Oxide Synthase/antagonists & inhibitors.
J Pharmacol Exp Ther 2002 Oct;303(1):52-7
N-
(4-
nitrophenacyl)-
2-
methylimidazole
0
*Imidazoles
*Nitrobenzenes
Nitric Oxide Synthase/antagonists & inhibitors.
Blood 2001 May 15;97(10):32-8
N-
(4-
nitrophenacyl)imidazole
0
*Imidazoles
*Nitrobenzenes
Nitric Oxide Synthase/antagonists & inhibitors.
Nitric Oxide 2001;5(1):32-8
aminoethyl-
isothiourea
0
Thiourea/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Crit Care Med 2000 Aug;28(8):2697-706
kikkanol D
0
*Sesquiterpenes
Nitric Oxide Synthase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 2000 May;48(5):651-6
kikkanol F
0
*Sesquiterpenes
Nitric Oxide Synthase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 2000 May;48(5):651-6
kikkanol E
0
*Sesquiterpenes
Nitric Oxide Synthase/antagonists & inhibitors.
Chem Pharm Bull (Tokyo) 2000 May;48(5):651-6
GW 274150
0
*Sulfides
Nitric Oxide Synthase/antagonists & inhibitors.
Bioorg Med Chem Lett 2000 Mar 20;10(6):597-600
GW 273629
0
*Sulfones
Nitric Oxide Synthase/antagonists & inhibitors.
Bioorg Med Chem Lett 2000 Mar 20;10(6):597-600
7-
chloro-
3-
imino-
5-
methyl-
2-
azabicyclo(4.1.0)heptane
0
*Amidines
Heterocyclic Compounds, 2-Ring
Nitric Oxide Synthase/antagonists & inhibitors.
Biochem Biophys Res Commun 2000 Apr 13;270(2):663-7
cyclolinteinone
159934-16-4
*Cyclohexanones
4-Butyrolactone/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Biochem J 2000 Mar 15;346( Pt 3):793-98
nepalolide A
0
*Anthracenes
Nitric Oxide Synthase/antagonists & inhibitors.
Br J Pharmacol 1999 Sep;128(2):345-56
fraxiden
0
*Coumarins
Nitric Oxide Synthase/antagonists & inhibitors.
Planta Med 1999 oct;65(7):656-8
alisol B monoacetate
0
*Cholestenones
Nitric Oxide Synthase/antagonists & inhibitors.
Biol Pharm Bull 1999 Oct;22(10):1147-9
N(delta)-
(4,5-
dihydrothiazol-
2-
yl)ornithine
0
*Thiazoles
Ornithine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Bioorg Med Chem 1999 Sep;7(9):1787-96
4,8-
dimethoxy-
1-
vinylcarboline
0
*Carbolines
Nitric Oxide Synthase/antagonists & inhibitors.
Arch Pharm Res 1999 Aug;22(4):410-3
4-
methoxy-
1-
vinylcarboline
0
*Carbolines
Nitric Oxide Synthase/antagonists & inhibitors.
Arch Pharm Res 1999 Aug;22(4):410-13
BN 80933
0
*Pyrazines
*Thiophenes
Nitric Oxide Synthase.
Cell Mol Life Sci 1999 Jul;55(8-9):1029-35
N(omega)-
nitroarginine-
2,4-
diaminobutryic amide
0
Nitroarginine
Nitric Oxide Synthase.
J Med Chem 1999 Aug 12;42(16):3147-53
S,S'-
1,4-
phenylene-
bis(1,2-
ethanediyl)bis-
isothiourea
0
Thiourea/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Carcinogenesis 1999 Apr;20(4):641-4
yomogin
0
*Sesquiterpenes, Eudesmane
Nitric Oxide Synthase/antagonists & inhibitors.
Arch Pharm Res 1998 Aug;21(4):481-4
HMN 1180
0
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
J Pharmacol Exp Ther 1998 Dec;287(3):1063-7
4-
methyl-
5-
pentylpyrrolidin-
2-
imine
0
*Imines
*Pyrrolidines
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1998 Sep 10;41(19):3675-83
alpha-
fluoro-
N-
(3-
(amimomethyl)phenyl)acetamidine
0
*Amidines
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1998 Jul 16;41(15):2858-71
N-
(3-
(aminomethyl)phenyl)-
2-
furanylamidine
0
*Amidines
*Furans
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1998 Jul 16;41(15):2858-71
7-
(2-
ethylbutyl)hexahydro-
1H-
azepin-
2-
imine
0
*Azepines
*Imines
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1998 Apr 23;41(9):1361-6
hexahydro-
7-
propyl-
1H-
azepin-
2-
imine
0
*Azepines
*Imines
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1998 Apr 23;41(9):1361-6
hexahydro-
3-
(2-
propenyl)-
1H-
azepin-
2-
imine
0
*Azepines
*Imines
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1998 Apr 23;41(9):1361-6
N(5)-
(1-
imino-
3-
butenyl)ornithine
0
Ornithine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
J Biol Chem 1998 Apr 10;273(15):8882-9
N-
(5-
amino-
6,7-
dihydroxyheptyl)ethanimidamide
0
*Fatty Alcohols
*Imines
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1998 Mar 12;41(6):775-7
N(omega)-
propylarginine
0
Arginine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1997 Nov 21;40(24):3869-70
N(omega)-
hydroxy-
N(omega)-
propargylarginine
0
Arginine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Bioorg Med Chem 1997 Aug;5(8):1601-8
N(omega)-
propargylarginine
0
Arginine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Bioorg Med Chem 1997 Aug;5(8):1601-8
pyrazole-
1-
carboxamidine
0
*Pyrazoles
Nitric Oxide Synthase/antagonists & inhibitors.
Biochem Pharmacol 1997 Aug 1;54(3):409-17
4-
amino-
tetrahydrobiopterin
0
Biopterin/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Biochemistry 1997 Jul 8;36(27):8422-7
3-
bromo-
7-
nitroindazole
0
*Indazoles
Nitric Oxide Synthase/antagonists & inhibitors.
Eur J Pharmacol 1997 Apr 11;324(1):11-20
S-
ethyl N-
(4-
(trifluoromethyl)phenyl)isothiourea
163490-40-2
Thiourea/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
J Med Chem 1997 Jun 6;40(12):1901-5
N-
(3-
(aminomethyl)benzyl)acetamidine
0
*Amidines
*Benzylamines
Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
J Biol Chem 1997 Feb 21;272(8):4959-63
6-
nitroindazole
7597-18-4
*Indazoles
Nitric Oxide Synthase/antagonists & inhibitors.
Pain 1996 Aug;66(2-3):313-9
ARL 17477
0
*Amidines
Nitric Oxide Synthase/antagonists & inhibitors.
J Cereb Blood Flow Metab 1996 Jul;16(4):599-604
2-
mercaptoethylguanidine
1190-74-5
*Guanidines
Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
1-
(2-
trifluoromethylphenyl)imidazole
25371-96-4
*Imidazoles
Nitric Oxide Synthase/antagonists & inhibitors.
Br J Pharmacol 1995 Nov;116(5):2349-50
2-
amino-
5,6-
dihydro-
6-
methyl-
4H-
1,3-
thiazine
0
*Thiazines
Nitric Oxide Synthase/antagonists & inhibitors.
Mol Pharmacol 1995 Apr;47(4):831-4
N(G)-
monomethylarginine acetate
0
Arginine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
J Pharmacol Exp Ther 1995 Mar;272(3):1011-5
N(6)-
(1-
iminoethyl)lysine
0
Lysine/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
J Med Chem 1994 Nov 11;37(23):3886-8
S-
ethylthiocitrulline
0
Citrulline/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
J Biol Chem 1994 Oct 28;269(43):26677-83
carboxyebselen
153871-75-1
*Organoselenium Compounds
Nitric Oxide Synthase/antagonists & inhibitors.
J Physiol Pharmacol 1994 Mar;45(1):55-67
S-
methylthiocitrulline
156719-41-4 L-
Ornithine, N5-
(imino(methylthio)methyl)
Citrulline/*analogs & derivatives
Thiourea/*analogs & derivatives
Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
J Med Chem 1994 Apr 1;37(7):885-7
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