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3-Oxo-5-alpha-Steroid 4-Dehydrogenase

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Definition: An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.      Other names Testosterone delta-4-5-alpha-Reductase; Testosterone 5-alpha-Reductase; 5-alpha-Reductase, Testosterone; 3-Keto-5-alpha-Steroid delta-4-Dehydrogenase; delta-4-Dehydrogenase, 3-Keto-5-alpha-Steroid; delta-4-5-alpha-Reductase, Testosterone; delta-4-5-alpha Reductase, Steroid; Testosterone delta 4 5 alpha Reductase; Testosterone 5 alpha Reductase; Steroid delta 4 5 alpha Reductase; Steroid 5 alpha Reductase; Reductase, Steroid delta-4-5-alpha; Reductase, Steroid 5Alpha; NADH 5 alpha Reductase; 5Alpha Reductase, Steroid; 5-alpha-Reductase, Steroid; 5 alpha Reductase, Testosterone; 4 Ene 5 alpha Reductase; 4 Ene 3 Oxosteroid 5alpha Reductase; 3 Oxo 5 alpha Steroid 4 Dehydrogenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SPET 085  0   *Plant Extracts 3-Oxo-5-alpha-Steroid 4-Dehydrogenase. Adv Ther 2010 Aug;27(8):555-63
Srd5a2 protein, rat  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase.
Srd5a1 protein, rat  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase.
Srd5a3 protein, mouse  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase.
Srd5a2 protein, mouse  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase.
SRD5A3 protein, human  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase.
SRD5A2 protein, human  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase.
SRD5A1 protein, human  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase.
Pseudovaginal perineoscrotal hypospadias  0   *Hypospadias *Steroid Metabolism, Inborn Errors *46, XY Disorders of Sex Development 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/deficiency.
17-p-bromophenylcarbamoyloxypregn-4-ene-3,20-dione  0   *Carbamates Progesterone/*analogs & derivatives 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 2007 Oct;107(1-2):48-56
17-phenylcarbamoyloxypregn-4-ene-3,20-dione  0   *Carbamates Progesterone/*analogs & derivatives 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 2007 Oct;107(1-2):48-56
Srd5a1 protein, mouse  EC 1.3.99.5   *Membrane Proteins *3-Oxo-5-alpha-Steroid 4-Dehydrogenase. Proc Natl Acad Sci U S A 2006 Sep 26;103(39):14602-7
steroid-5alpha-reductase type 2  EC 1.3.99.5   *3-Oxo-5-alpha-Steroid 4-Dehydrogenase. J Enzyme Inhib Med Chem 2002 Jun;17(3):187-96
steroid-5alpha-reductase type 1  EC 1.3.99.5   *3-Oxo-5-alpha-Steroid 4-Dehydrogenase. J Enzyme Inhib Med Chem 2002 Jun;17(3):187-96
8-allyl-7-hydroxy-2H-benzopyran-2-one  0   *Coumarins 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2361-3
N-(1-(4-trifluoromethylphenyl)cyclopentenyl)-3-oxo-4-aza-5a-androst-1-ene-17beta-carboxamide  0   *Androstenes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Endocrinology 2001 Nov;142(11):4652-62
3'-geranyl-2',3,4,4'-tetrahydroxychalcone  0   *Chalcones 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Phytochemistry 2000 Aug;54(8):737-9
4-methyl-benzo(c)quinolizin-3-one  0   *Quinolizines 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Org Chem 2000 Nov 17;65(23):8093-5
8-chloro-2,3,5,6-tetrahydro-4-methylbenzo(c)quinolizin-3-one  0   *Quinolizines 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Med Chem 2000 Oct 5;43(20):3718-35
2,3,5,6-tetrahydro-4,8-dimethylbenzo(c)quinolizin-3-one  0   *Quinolizines 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Med Chem 2000 Oct 5;43(20):3718-35
Z 350  0   *Indoles *Piperazines 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Sep;290(3):1013-8
SNA 4606-1  0   *Macrolides 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Antibiot (Tokyo) 1999 Feb;52(2):175-7
L 685273  0   *Pregnenediones 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Endocrinology 1996 Jul;137(7):2703-10
N-(1',1'-dimethylethyl)-3-fluoroandrost-3,5-dien-17-carboxamide  0   *Androstadienes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Bioorg Med Chem 1996 Jan;4(1):55-60
DET2 protein, Arabidopsis  0   *Arabidopsis Proteins 3-Oxo-5-alpha-Steroid 4-Dehydrogenase. Science 1996 Apr 19;272(5260):398-401
LY 300502  0   *Quinolones 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Prostate Suppl 1996;6:62
N,N-diethyl-3-oxo-4-azaandrost-1-ene-17-carboxamide  92472-70-3   Finasteride/*analogs & derivatives 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 1995 Jan;52(1):105-12
L 651723  0   *Androstenes *Azasteroids 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Biol Reprod 1994 Jun;50(6):1244-50
FCE 28260  155651-56-2   *Androstenes *Azasteroids 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 1994 Jun;49(4-6):289-94
FCE 28175  156990-25-9   *Androstenes *Azasteroids 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 1994 Jun;49(4-6):289-94
FCE 27837  155651-61-9   *Androstenes *Azasteroids 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 1994 Jun;49(4-6):289-94
LY 191704  146117-78-4 Benzo(f)quinolin-3(2H)-one, 8-chloro-1,4,4a,5,6,10b-hexahydro-4-methyl-, trans  *Quinolones 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Proc Natl Acad Sci U S A 1993 Jun 1;1993;90(11):5277-81
(5alpha)-23-methyl-4-aza-21-norchol-1-ene-3,20-dione  103497-68-3 4-Aza-21-norchol-1-ene-3,20-dione, 23-methyl-, (5alpha)  *Azasteroids 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Clin Pharmacol Ther1992 Oct;52(4):409-12
N,N-diethyl-4-methoxy-3-oxo-4-aza-5-androstene-17-carboxamide  106649-71-2   *Androstenes *Azasteroids 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Int J Androl 1991 Oct;14(5):359-63
17-(N,N-diisopropylcarbamoyl)estra-1,3,5(10)-triene-3-sulfonic acid  131267-92-0   *Estrenes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Steroids 1991;56(1):4
17-(N-t-butylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acid  124651-01-0   *Estrenes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 1990;37(4):575
17-(N,N-diisopropylcarboxamide)estra-1,3,5(10)-triene-3-carboxylic acid  124650-99-3   *Estrenes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Steroid Biochem Mol Biol 1990;37(4):575
2-hydroxynonafluoroazobenzene  129520-55-4   *Azo Compounds *Fluorobenzenes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Med Chem 1990;33(9):2452
4-hydroxynonafluoroazobenzene  25593-03-7   *Azo Compounds *Fluorobenzenes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Med Chem 1990;33(9):2452
17-(N,N,-diisopropylcarbamoyl)androst-3,5-diene-3-carboxylic acid  119190-36-2   *Androstadienes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Biochemistry 1990;29(11):2815
WS 9659 B  123313-61-1   *Phenazines 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Antibiot (Tokyo) 1989;42(8):1221
lavanducyanin  122228-60-8   *Phenazines 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Antibiot (Tokyo) 1989;42(7):1196
4-methoxyandrostenedione  20986-46-3   Androstenedione/*analogs & derivatives 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Steroids 1988;52(3):237
17-N,N-diisopropylcarbamoyl-4-azaandrostan-3-one  89631-79-8   *Azasteroids Dihydrotestosterone/*analogs & derivatives 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Endocrinology 1986 Jan;118(1):132-7
20-(hydroxymethyl)-4-methyl-4-aza-2-oxapregnan-3-one  96000-11-2   *Pregnanes *Steroids, Heterocyclic 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. J Med Chem 1985;28(6):831
testosterone formate  3129-42-8   Testosterone/*analogs & derivatives 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Acta Physiol Lat Am 1979;29(1):5
17-acetoxy-6-methylene-4-pregnene-3,20-dione  32634-95-0   Progesterone/*analogs & derivatives 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Steroids 1981;38(2):121
Ro 6-1963  4136-08-7 6 beta methoxy-9 beta,10 alpha-pregna-4,6-dien-3,20-dione  *Pregnadienes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Experientia 32(10):1250;1976
4-androsten-3-one-17 beta-carboxylic acid  302-97-6   *Androstenes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Biol Reprod 1980;23(4)):767; J Biol Chem 248(12):4280;1973; J Reprod Fert 53(1):45;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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