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Sodium-Hydrogen Antiporter

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Definition: A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.  a carrier protein    Other names Sodium Proton Antiporter; Sodium Hydrogen Exchanger; Sodium Hydrogen Antiporter; Exchanger, Sodium-Hydrogen; Antiporter, Sodium-Proton; Antiporter, Sodium-Hydrogen; Sodium-Proton Antiporter; Sodium-Hydrogen Exchanger; Na(+)-H(+)-Exchanger; Na(+)-H(+)-Antiporter
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NHE4 protein, human  0   *Sodium-Hydrogen Antiporter. Am J Physiol Cell Physiol. 2012 Jan;302(2):C412-8
Slc9a9 protein, rat  0   *Sodium-Hydrogen Antiporter. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):835-43.
NHE3 protein, Toxoplasma gondii  0   *Protozoan Proteins *Sodium-Hydrogen Antiporter. Exp Cell Res. 2011 Jun 10;317(10):1382-96
NHX4 protein, Arabidopsis  0   *Sodium-Hydrogen Antiporter *Arabidopsis Proteins. Plant J 2002 Jun;30(5):529-39
PBO-5 protein, C elegans  0   *Sodium-Hydrogen Antiporter *Caenorhabditis elegans Proteins. Cell 2008 Jan 11;132(1):149-60
PBO-4 protein, C elegans  0   *Sodium-Hydrogen Antiporter *Caenorhabditis elegans Proteins. Cell 2008 Jan 11;132(1):149-60
Vnx1 protein, S cerevisiae  0   *Sodium-Hydrogen Antiporter *Saccharomyces cerevisiae Proteins. J Biol Chem 2007 Aug 17;282(33):24284-93
BIIB 723  0   *Guanidines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Medicina (B Aires). 2006;66(5):392-8
(5-(4-fluorophenyl)furan-2-ylcarbonyl)guanidine  0   *Furans *Guanidines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Eur J Pharmacol. 2007 Jul 12;567(1-2):131-8
SLC9B1 protein, human  0   *Sodium-Hydrogen Antiporter. Mol Biol Rep 2006 Sep;33(3):175-80
NHE9 protein, mouse  0   *Sodium-Hydrogen Antiporter. J Neurosci 2006 Sep 27;26(39):9944-55
Slc9a2 protein, mouse  0   *Sodium-Hydrogen Antiporter.
Slc9a2 protein, rat  0   *Sodium-Hydrogen Antiporter.
CHX21 protein, Arabidopsis  0   *Sodium-Hydrogen Antiporter *Arabidopsis Proteins. J Exp Bot 2006;57(5):1201-10
MAST205 protein, rat  EC 2.7.1.37   *Microtubule-Associated Proteins *Protein-Serine-Threonine Kinases Sodium-Hydrogen Antiporter/antagonists & inhibitors. Am J Physiol Renal Physiol 2006 Feb;290(2):F428-37
NHE6 protein, mouse  0   *Sodium-Hydrogen Antiporter. Peptides 2005 May;26(5):863-73
NHE8 protein, rat  0   *Sodium-Hydrogen Antiporter. Am J Physiol Gastrointest Liver Physiol 2005 Jul;289(1):G36-41
(5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl)guanidine  0   *Guanidines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Eur J Pharmacol. 2005 Mar 28;511(2-3):175-82
Sod2 protein, S pombe  0   *Sodium-Hydrogen Antiporter *Schizosaccharomyces pombe Proteins. Mol Cell Biol 2005 May;25(10):3945-55
CHX17 protein, Arabidopsis  0   *Sodium-Hydrogen Antiporter *Arabidopsis Proteins. Plant J 2004 Sep;39(6);834-46
nhx-1 protein, C elegans  0   *Sodium-Hydrogen Antiporter *Cation Transport Proteins *Caenorhabditis elegans Proteins.
NHX1 protein, S cerevisiae  0   *Sodium-Hydrogen Antiporter *Saccharomyces cerevisiae Proteins.
NhaB protein, E coli  0   *Sodium-Hydrogen Antiporter *Escherichia coli Proteins.
SLC9A1 protein, human  0   *Sodium-Hydrogen Antiporter *Cation Transport Proteins.
Slc9a1 protein, mouse  0   *Sodium-Hydrogen Antiporter *Cation Transport Proteins.
Slc9a4 protein, mouse  0   *Sodium-Hydrogen Antiporter.
SLC9A8 protein, human  0   *Sodium-Hydrogen Antiporter.
NHE protein, mouse  0   *Sodium-Hydrogen Antiporter Spermatozoa. Nat Cell Biol 2003 Dec;5(12);1117-1122
NHX-2 protein, C elegans  0   *Sodium-Hydrogen Antiporter *Caenorhabditis elegans Proteins. Biochem J 1998 Jun 1;332( Pt 2):565-72
SLC9A9 protein, human  0   *Sodium-Hydrogen Antiporter Protein Isoforms. J Med Genet 2003 Oct;40(10):733-40
SOS1 protein, Arabidopsis  0   *Sodium-Hydrogen Antiporter *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2000 Jun 6;97(12):6896-901
Slc9a8 protein, mouse  0   *Sodium-Hydrogen Antiporter. Am J Physiol Renal Physiol 2003 Mar;284(3):F467-73
Slc9a1 protein, rat  0   *Sodium-Hydrogen Antiporter. J Biol Chem 2002 Mar 22;277(12):9668-75
FR 183998  0   *Guanidines *Thiophenes Sodium-Hydrogen Antiporter/antagonists & inhibitors. Brain Res 2001 Dec 20;922(2):223-8
SLC9A6 protein, human  0   *Sodium-Hydrogen Antiporter. J Biol Chem 2001 Dec 28;276(52):49221-7
BMS 284604  0   *Cyclopropanes *Guanidines Sodium-Hydrogen Antiporter/antagonists & inhibitors. J Med Chem 2001 Sep 27;44(20):3302-10
CNH1 protein, Candida albicans  0   *Fungal Proteins *Sodium-Hydrogen Antiporter. FEBS Lett. 2001 Aug 24;504(1-2):11-5
SOD2 protein, Zygosaccharomyces rouxii  0   *Fungal Proteins *Sodium-Hydrogen Antiporter. J Biotechnol 2001 Jun 15;88(2):151-8
(7-(5-fluoro-2-methylphenyl)-4-methyl-7,8-dihydro-5(6H)-quinolinylideneamino)guanidine  0   *Guanidines *Quinolines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Eur J Pharmacol 2001 May 18;420(1):1-8
SLC9A7 protein, human  0   *Sodium-Hydrogen Antiporter. J Biol Chem 2001 May 18;276(20):17387-94
SL 59.1227  0   *Benzamides *Imidazoles Sodium-Hydrogen Antiporter/antagonists & inhibitors. Br J Pharmacol 2000 Nov;131(6):1188-94
N-(aminoiminomethyl)-1-(2-phenylethyl)-1H-indole-2-carboxamide  0   *Guanidines *Indoles Sodium-Hydrogen Antiporter/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1999 Nov;47(11):1538-48
BIIB 513  0   *Mesylates Sodium-Hydrogen Antiporter/antagonists & inhibitors. Circulation 1999 Dec 21-28;100(25) 2519-26; discussion 2469-72
FR 168888  0   *Benzyl Alcohols *Guanidines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Jpn J Pharmacol 1999 Aug;80(4):295-302
MS 31-038  181048-36-2   *Quinolines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Arzneimittelforschung 1999 Apr;49(4):304-10
EMD 96785  0   *Guanidines *Sulfones Sodium-Hydrogen Antiporter/antagonists & inhibitors. J Membr Biol 1999 Mar 1;168(1):39-45
EMD 84021  0   *Guanidines *Sulfones Sodium-Hydrogen Antiporter/antagonists & inhibitors. J Membr Biol 1999 Mar 1;168(1):39-45
EMD 94309  0   *Guanidines *Sulfones Sodium-Hydrogen Antiporter/antagonists & inhibitors. J Membr Biol 1999 Mar 1;168(1):39-45
NHX1 protein, Arabidopsis  0   *Sodium-Hydrogen Antiporter *Cation Transport Proteins *Arabidopsis Proteins. Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1480-5
sodium-hydrogen exchanger 5  0   *Sodium-Hydrogen Antiporter. J Biol Chem 1999 Feb 12;274(7):4377-82
2-aminoperimidine  0   *Quinazolines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Cell Physiol Biochem 1998;8(4):212-23
NhaP protein, Pseudomonas aeruginosa  0   *Bacterial Proteins *Sodium-Hydrogen Antiporter. Biochim Biophys Acta 1998 Jul 9;1398(3):330-4
N-diaminomethylene-2-methyl-5-methylsulfonyl-4-pyrrolobenzamide, hydrochloride  0   *Benzamides *Pyrroles Sodium-Hydrogen Antiporter/antagonists & inhibitors. J Pharmacol Exp Ther 1998 Jul;286(1):175-83
NhaD protein, Vibrio  0   *Bacterial Proteins *Sodium-Hydrogen Antiporter Bacterial Proteins. Biochem Biophys Acta 1998 Mar 2;1369(2):213-20
N-(2,4-diethyl-3-oxo-3,4-dihydro-2H-benzo(1,4)oxazine-7-carbonyl)guanidine  0   *Guanidines *Oxazines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Dec;45(12):1975-83
N-(2-ethyl-4-isopropyl-3-oxo-3,4-dihydro-2H-benzo(1,4)oxazine-7-carbonyl)guanidine  0   *Guanidines *Oxazines Sodium-Hydrogen Antiporter/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Dec;45(12):1975-83
NhaA protein, E coli  0   *Sodium-Hydrogen Antiporter *Escherichia coli Proteins. J Biol Chem 1996 Dec 13;271(50):32288-92
NHA1 protein, S cerevisiae  0   *Sodium-Hydrogen Antiporter *Cation Transport Proteins *Saccharomyces cerevisiae Proteins. FEBS Lett 1996 May 27;387(1):89-93
sodium-hydrogen exchanger regulatory factor  0   *Phosphoproteins *Sodium-Hydrogen Antiporter. J Clin Invest 1995 May;95(5):2143-9
sodium-hydrogen exchanger 3  0   *Sodium-Hydrogen Antiporter. J Biol Chem 1994 Jun 3;269(22):15613-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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