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Cytochrome P-450 CYP2D6

More information in Books or onNLM PubMed
Definition: A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.  do not confuse with other cytochrome P-450 CYP's    Other names P450 2D6, Cytochrome; P-450 CYP2D6, Cytochrome; Monooxygenase, Sparteine; Imipramine 2 Hydroxylase; Hydroxylase, Debrisoquine; Debrisoquine 4 Monooxygenase; Debrisoquine 4 Hydroxylase; Cytochrome P 450 CYP2D6; CYP2D6, Cytochrome P-450; 4-Monooxygenase, Debrisoquine; 4-Hydroxylase, Debrisoquine; 2-Hydroxylase, Imipramine; Sparteine Monooxygenase; Imipramine 2-Hydroxylase; Debrisoquine 4-Monooxygenase; Cytochrome P450 2D6; CYP 2D6; Debrisoquine Hydroxylase; Debrisoquine 4-Hydroxylase; CYP2D6
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-((2-ethyl-4-methyl-1H-imidazol-5-yl)methyl)-4-(4-(trifluoromethyl)-2-pyridinyl)piperazine  0   *Imidazoles *Pyridines Cytochrome P-450 CYP2D6/antagonists & inhibitors. Chem Res Toxicol 2004 Feb;17(2):174-84
3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin  0   *Quaternary Ammonium Compounds *Coumarins Cytochrome P-450 CYP2D6. Drug Metab Dispos 2001 Sep;29(9):1196-200
methylenedoxyamphetamine demethylenase  EC 1.-   *Oxidoreductases Cytochrome P-450 CYP2D6. Biochem Pharmacol 2000 Jun 15;59(12):1563-71
dextromethorphan O-demethylase  EC 1.-   *Cytochrome P-450 Enzyme System *Oxidoreductases, O-Demethylating Cytochrome P-450 CYP2D6. Anal Biochem 1987;162(1):24

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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