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Intramolecular Transferases

More information in Books or onNLM PubMed
Definition: Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.     
Examples 2-Acetolactate Mutase; Chorismate Mutase; Methylmalonyl-CoA Mutase; Phosphotransferases (Phosphomutases) 		Other names Transferases, Intramolecular; Mutases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
thalianol synthase, Arabidopsis  EC 5.4.-   *Intramolecular Transferases *Arabidopsis Proteins. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16116-21.
marneral synthase, Arabidopsis  EC 5.4.-   *Intramolecular Transferases *Arabidopsis Proteins. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16116-21.
parkeol synthase, Oryza sativa  EC 5.4.-   *Intramolecular Transferases Plant Proteins. Org Lett. 2011 May 20;13(10):2678-81
achilleol B synthase, Oryza sativa  EC 5.4.-   *Intramolecular Transferases Plant Proteins. Org Lett. 2011 May 20;13(10):2678-81
4-methylmuconolactone methylisomerase, Pseudomonas reinekei  EC 5.4.-   *Bacterial Proteins *Intramolecular Transferases. J Biol Chem 2009 Nov 20;284(47):32709-16
ethylmalonyl-CoA mutase, Rhodobacter sphaeroides  EC 5.4.99.-   *Intramolecular Transferases. J Biol Chem 2008 Nov 21;283(47):32283-93
LUP1 protein, Arabidopsis  EC 5.4.-   *Intramolecular Transferases *Arabidopsis Proteins. Org Lett 2006 Nov 23;8(24):5589-92
glutamate 2,3-aminomutase, Clostridium difficile  EC 5.4.3.-   *Intramolecular Transferases. Biochim Biophys Acta 2007 Feb;1774(2):286-96
LAS1 protein, Arabidopsis  EC 5.4.99.7   *Intramolecular Transferases *Arabidopsis Proteins. Plant Cell Physiol 2006 May;47(5):565-71
N-acetylglucosamine-phosphate mutase, Candida albicans  EC 5.4.-   *Intramolecular Transferases Fungal Proteins. J Biol Chem 2006 Jul 14;281(28):19740-7
precorrin-8x methylmutase, Thermoplasma acidophilum  EC 5.4.99.-   *Intramolecular Transferases. Proteins 2005 Feb 15;58(3):751-4
alanine 2,3-aminomutase  EC 5.4.-   *Intramolecular Transferases. Anal Chem. 2005 Oct 15;77(20):6737-40
N(5)-carboxyaminoimidazole ribonucletide mutase  EC 5.4.99.-   *Intramolecular Transferases. Acta Crystallogr D Biol Crystallogr 2004 Oct;60(Pt 10):1753-60
PUS9 protein, S cerevisiae  EC 5.4.99.-   *Intramolecular Transferases *Saccharomyces cerevisiae Proteins. J Biol Chem 2004 Dec 17;279(51):52998-3006
Glf protein, E coli  EC 5.4.99.9   *Intramolecular Transferases *Escherichia coli Proteins Flavoproteins.
TruD protein, E coli  EC 5.4.99.12   *Intramolecular Transferases *Escherichia coli Proteins. FEBS Lett 2004 May 7;565(1-3):59-64
isomultiflorenol synthase  EC 5.4.99.-   *Intramolecular Transferases. Eur J Biochem 2001 Dec;268(23):6311-7
jadI protein, Streptomyces  EC 5.4.99.-   *Bacterial Proteins *Intramolecular Transferases. J Nat Prod 2001 Aug;64(8):1077-80
hydroxylaminobenzene mutase  EC 5.4.-   *Intramolecular Transferases. Applied Environ Microbiol 2000 Jul;66(7):2965-71
2,3-diaminopropyl sulfate  0   *Amines Propane/*analogs & derivatives Intramolecular Transferases/antagonists & inhibitors. Biochemistry 2000 Mar 21;39(11):3091-6
D-lysine 5,6-aminomutase  EC 5.4.3.4   *Intramolecular Transferases. J Biol Chem 2000 Jan 7;275(1):106-14
3-hydroxylaminophenol mutase  EC 5.4.99.-   *Intramolecular Transferases. J Bacteriol 1999 Mar;181(5):1444-50
lupeol synthase  EC 5.4.99.-   *Intramolecular Transferases. Phytochemistry 1998 Dec;49(7):1905-11
tocopherol cyclase  EC 5.4.99.-   *Intramolecular Transferases Arabidopsis Proteins. Bioorg Med Chem 1996 Jul;4(7):1129-34
3,6-diaminohexanoate aminomutase  EC 5.4.3.3   *Intramolecular Transferases.
UDP-galactopyranose mutase  EC 5.4.99.9   *Intramolecular Transferases Flavoproteins. J Bacteriol 1996 Feb;178(4):1047-52
PchA protein, Pseudomonas aeruginosa  EC 5.4.99.6   *Bacterial Proteins *Intramolecular Transferases. Mol Gen Genet 1995 Nov 15;249(2):217-28
pseudouridine synthases  EC 5.4.99.-   *Intramolecular Transferases. RNA 1995 Jun;1(4):437-48
16S RNA pseudouridine 516 synthase, E coli  EC 5.4.99.-   *Intramolecular Transferases *Escherichia coli Proteins RNA, Ribosomal, 16S. Biochemistry 1995 Jul 11;34(27):8904-13
CobH protein, Pseudomonas denitrificans  EC 5.4.99.-   *Bacterial Proteins *Intramolecular Transferases. J Bacteriol 1992 Feb;174(3):1043-9
ribB protein, E coli  143242-07-3   *Heat-Shock Proteins *Intramolecular Transferases *Escherichia coli Proteins. J Bacteriol 1991;173(19):5999
DEG1 protein, S cerevisiae  EC 5.4.99.-   *Intramolecular Transferases *Saccharomyces cerevisiae Proteins. Curr Genet 1991;19(1):1
squalene-hopene cyclase  EC 5.4.99.-   *Intramolecular Transferases. Eur J Biochem 1990;194(1):75
L-3,4-dihydroxy-2-butanone-4-phosphate synthase  EC 5.4.-   *Intramolecular Transferases Saccharomyces cerevisiae Proteins. J Biol Chem 1990;265(32):19479
luxH protein, Vibrio harveyi  EC 5.4.99.-   *Bacterial Proteins *Intramolecular Transferases Luminescent Agents. J Biol Chem 1990;265(6):3513
4-methylmuconolactone methyl-isomerase  EC 5.3.3.-   *Intramolecular Transferases. Biochem J 1989;262(1):303
glutamate-1-semialdehyde 2,1-aminomutase  EC 5.4.3.8   *Intramolecular Transferases. Carlsberg Res Commun 1988;53(1):11
isochorismate synthase  EC 5.4.4.2   *Intramolecular Transferases. J Bacteriol 1989;171(2):775
pyrogallol-phloroglucinol isomerase  EC 5.4.99.-   *Intramolecular Transferases. J Bacteriol 1988;170(6):2472
4-carboxymethyl-methylbut-2-ene-1,4-olide isomerase  EC 5.4.99.-   *Intramolecular Transferases. Science 1987;238(4832):1395
2-methyleneglutarate mutase  EC 5.4.99.4   *Intramolecular Transferases. Philos Trans R Soc Lond (Biol) 1985;311(1152):531
isomaltulose synthase  EC 5.4.99.11   *Intramolecular Transferases. Biochem J 1984;220(1):213
2,3-oxidosqualene-beta-amyrin-cyclase  EC 5.4.99.-   *Intramolecular Transferases. Biochem Soc Trans 1983;11(5):537
i-cholesterol isomerase  EC 5.4.99.-   *Intramolecular Transferases. J Steroid Biochem 1983;19(4):1391
deacetoxycephalosporin C synthetase  EC 5.4.99.-   *Intramolecular Transferases *Penicillin-Binding Proteins. Can J Microbiol 1983;29(5):488
tyrosine 2,3-aminomutase  EC 5.4.3.6   *Intramolecular Transferases. Biochim Biophys Acta 264(1):1;1972
tRNA-pseudouridine synthase I  EC 5.4.99.12   *Intramolecular Transferases. Biochem Biophys Res Commun 79(3):764;1977; J Biol Chem 249(4):1103;1974; J Biol Chem 252(18):6310;1977
lanosterol synthase  EC 5.4.99.7   *Intramolecular Transferases. Biochim Biophys Acta 530(1):17;1978; J Biol Chem 251(17):5155;1976; J Biol Chem 254(22):11258;1979; Mol Gen Genet 154(3):269;1977
cycloartenol synthase  EC 5.4.99.8   *Intramolecular Transferases. Biochem J 150(3):323;1975; Biochim Biophys Acta 176(4):892;1969
ornithine 5,4-aminomutase  EC 5.4.3.5   *Intramolecular Transferases. Biochemistry 12(14):297;1973
methylaspartate mutase  EC 5.4.99.1   *Intramolecular Transferases.
lysine 2,3-aminomutase  EC 5.4.3.2   *Intramolecular Transferases. J Biol Chem 245(7):1778;1970
leucine 2,3-aminomutase  EC 5.4.3.7   *Intramolecular Transferases. J Bacteriol 1979;140(3):1013; J Biol Chem 251(7):1859;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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