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Aryl Hydrocarbon Hydroxylases

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Definition: A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.     
Examples Aniline Hydroxylase; Benzopyrene Hydroxylase; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A 		Other names Monooxygenases, Xenobiotic; Monooxygenases, Microsomal; Hydroxylases, Aryl Hydrocarbon; Xenobiotic Monooxygenases; Microsomal Monooxygenases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
chlorzoxazone 6-hydroxylase, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. J Asian Nat Prod Res. 2012;14(4):382-95
cytochrome P-450 CYP3A65, zebrafish  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Oxidoreductases, N-Demethylating *Zebrafish Proteins. Toxicol Appl Pharmacol 2005 Jun 15;205(3):247-58
cytochrome P-450 CYP2D30 (marmoset)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem Pharmacol. 2004 Jul 1;68(1):165-75
Cyp3a62 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Oxidoreductases, N-Demethylating. J Pharmacol Exp Ther. 2004 Jun;309(3):1282-90
cytochrome P-450 CYP6B4, butterfly  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2():14593-8
cytochrome P-450 CYP6B17, butterfly  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Proc Natl Acad Sci U S A. 2003 Nov 25;100 Suppl 2():14593-8
deoxysarpagine hydroxylase  EC 1.14.14.-   *Aryl Hydrocarbon Hydroxylases. Bioorg Med Chem. 2002 Aug;10(8):2479-83
cytochrome P-450 CYP6B3 (butterfly)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Insect Mol Biol. 1995 Aug;4(3):149-60; Proc. Natl. Acad. Sci. U.S.A. 93:12200-12205(1996)
cytochrome P-450 CYP6B1 (butterfly)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Proc Natl Acad Sci U S A 1992 Nov 15;89(22):10920-4
cytochrome P-450 CYP3A37 (chicken)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Arch Biochem Biophys 2000 Jan 15;373(2):375-84
cytochrome P-450 CYP2A16 (hamster)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochim Biophys Acta 1999 Sep 3;1446(3):438-42
cytochrome P-450 CYP2B4 (rabbit)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases.
Cyp2a4 protein, mouse  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases.
Cyp2a1 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases.
CYP2C11 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid 16-alpha-Hydroxylase.
CYP2C9 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases.
CYP2C8 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases Taxoids.
CYP2C3 protein, Oryctolagus cuniculus  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochemistry 29:3743-3750(1990)
cytochrome P-450 CYP4A4 (rabbit)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Arch Biochem Biophys 2001 Sep 15;393(2):329-38; J. Biol. Chem. 262:13366-13371(1987)
Cytochrome P450 CYP2A7  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem J 1995 Feb 15;306( Pt 1):161-6
CYP3A43 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Mol Pharmacol 2001 Feb;59(2):386-92
CYP4F12 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem Biophys Res Commun 2001 Jan 26;280(3):892-7
CYP1A4 protein, Gallus gallus  EC 1.14.14.1   *Avian Proteins *Aryl Hydrocarbon Hydroxylases. Toxicol Appl Pharmacol 2000 Nov 1;168(3):177-82
Cyp3a9 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Oxidoreductases, N-Demethylating. Biochem Biophys Res Commun 1996 Apr 5;221(1):157-62
CYP2A13 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Cancer Res 2000 Sep 15;60(18):5074-9
Cyp2c40 protein, mouse  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Mol Pharmacol 2000 Aug;58(2):279-87
Cyp2b9 protein, mouse  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1999 Sep 1;369(1):89-99
CYP4F8 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem Biophys Res Commun 1999 Jul 22;261(1):169-74
Cyp2d2 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Pharmacogenetics 1999 Apr;9(2):171-81
cytochrome P-450 CYP2D16 (guinea pig)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Mol Cell Endocrinol 1998 Nov 25;146(1-2):129-36
Cyp2d22 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Arch Biochem Biophys 1998 Nov 1;359(1):115-21
cytochrome P-450 CYP3A14 (guinea pig)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem Mol Biol Int 1998 May;44(6):1245-53
cytochrome P-450 CYP2D15 (dog)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. J Biochem (Tokyo) 1998 Jan;123(1):162-8
CYP3A23 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Arch Biochem Biophys 1997 Jun 1;342(1):134-42
cytochrome P-450 CYP1A5  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Drug Metab Dispos 1997 Jul;25(7):779-83
cytochrome P-450 CYP1A3 (rainbow trout)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Xenobiotica 1997 Feb;27(2):175-87
cytochrome P-450 CYP2G1  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1997 Apr 15;340(2):208-14; Biochem Biophys Res Commun 1996 Jan 17;218(2):570-4
cytochrome P-450 CYP3A21 (marmoset)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Arch Biochem Biophys 1997 Mar 1;339(1):85-91
cytochrome P-450 CYP2D19 (marmoset)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Arch Biochem Biophys 1997 Mar 1;339(1):85-91
S-mephenytoin N-demethylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Oxidoreductases, N-Demethylating. Drug Metab Dispos 1996 Sep;24(9):948-54
CYP3A7 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem Biophys Res Commun 1996 Nov 12;228(2):312-7
Cyp2b10 protein, mouse  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Biochem Biophys Res Commun 1996 Sep 24;226(3):900-5
CYP2A8 protein, Mesocricetus auratus  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem Biophys Res Commun 1996 Aug 14;225(2):685-8
cytochrome P-450 CYP3A6 (rabbit)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Mol Pharmacol 1996 Jul;50(1):10-6
cytochrome P-450 CYP4B1  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Arch Biochem Biophys 1995 Aug 1;321(1):255-62
cytochrome P450, family 1, subfamily B, polypeptide 1  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Carcinogenesis 1995 Jun;16(6):1319-27
testosterone 2-alpha-hydroxylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1995 Jan 10;316(1):478-84
aklavinone 11-hydroxylase  EC 1.14.14.-   *Aryl Hydrocarbon Hydroxylases. J Bacteriol 1994 Nov;176(22):7096-101
cytochrome P-450 CYP2B5 (rabbit)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1994 Nov 1;314(2):367-75
cytochrome P-450 CYP2B11 (dog)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases Steroid Hydroxylases. Arch Biochem Biophys 1994 Nov 1;314(2):367-75
Cyp2b3 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. DNA Cell Biol 1994 Aug;13(8):781-92
CYP2K1 protein, Oncorhynchus mykiss  EC 1.14.14.1   *Fish Proteins *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1994 Jul;312(1):45-51
CYP2A11 protein, Oryctolagus cuniculus  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. J Biol Chem 1993 Aug 15;268(23):17253-60
CYP2A10 protein, Oryctolagus cuniculus  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. J Biol Chem 1993 Aug 15;268(23):17253-60
CYP2C18 protein, human  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases. Biochem Biophys Res Commun 1993 Jul 15;194(1):194-201
cytochrome P450 CYP3A10 (hamster)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. J Biol Chem 1991;266(31):21031
3-methylsulfonyl-4,5,3',4'-tetrachlorobiphenyl  104104-34-9   *Polychlorinated Biphenyls Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors. Fukuoka Igaku Zasshi 1987;78(5):199
steroid 15-alpha-hydroxylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Biochemistry 1986;25(17):4913
biphenyl-3-hydroxylase  EC 1.14.14.-   *Aryl Hydrocarbon Hydroxylases. Anal Biochem 1986;154(2):590
phenanthrene-9,10-epoxidase  EC 1.14.14.-   *Aryl Hydrocarbon Hydroxylases. Antibiot Med Biotekhnol 1986;31(3):196
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