encyclopedia of medical concepts
ψ
Distamycins
More information
in Books
or on
Definition
: Oligopeptide antibiotics from Streptomyces distallicus. Their binding to DNA inhibits synthesis of nucleic acids.
Pharmacological Action
Anti-Bacterial Agents
;
Nucleic Acid Synthesis Inhibitors
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
(2-
(diethylamino)ethyl)-
1-
methyl-
4-
(1-
methyl-
4-
(4-
formamido-
1-
methylimidazole-
2-
carboxamido)pyrrole-
2-
carboxamido)imidazole-
2-
carboxamide
0
*Distamycins
*Imidazoles.
J Am Chem Soc 2005 Jan 19;127(2):742-50
MEN 10716
0
*Distamycins.
Eur J Cancer 2002 Sep;38(13):1792-801
microgonotropen L2
0
*Benzimidazoles
*Distamycins
*Pyrroles.
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10590-5
3-
(1-
methyl-
4-
(1-
methyl4-
(1-
methyl-
4-
(8-
(2'-
carboxamidoethyloxy)-
7-
methoxy-
1,2,3,11a-
tetrahydro-
5H-
pyrrolo(2,1-
c)(1,4)benzodiazepin-
5-
one)pyrrole-
2-
carboxamido)pyrrole-
2-
carboxamido)pyrrole-
2-
carboxamido)propionamidine
0
*Benzodiazepinones
*Distamycins.
Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1219-29
MT 17
0
*Distamycins.
Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1365-79
MT 12
0
*Distamycins.
Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1365-79
AR-
1-
144
0
*Distamycins.
Eur J Biochem 1999 Aug;263(3):646-55
PNU 157977
0
*Distamycins
*Nitrogen Mustard Compounds.
Anticancer Drug Des 1999 Feb;14(1):71-6
PNU 151807
0
*Distamycins.
Br J Cancer 1999 Jun;80(7):991-7
PNU 153429
0
*Distamycins.
J Pharm Biomed Anal 1998 Mar;16(7):1153-8
chloroacetyldistamycin
0
*Distamycins.
Rocz Akad Med Bialymst 1997;42(1):129-40
FCE 25450A
0
*Distamycins.
Int J Cancer 1997 Sep 4;72(5):810-4
FCE 27784
0
*Distamycins.
Br J Pharmacol 1997 Feb;120(3):537-43
microgonotropen pentaazapentabutylamine
0
*Distamycins.
Bioorg Med chem 1996 Jun;4(6):803-13
FCE 27266
0
*Distamycins.
Invasion Metastasis 1995;15(5-6):222-31
MEN 10710
0
*Distamycins
*Nitrogen Mustard Compounds.
Nucleic Acids Res 1996 Jan 15;24(2):311-5
distel(2+)
159506-80-6
*Distamycins
*Ellipticines.
Biochem Pharmacol 1995 Jul 31;50(3):424-8
2-
imidazoledistamycin
142211-78-7
*Distamycins.
Proc Natl Acad Sci USA 1994 Aug 2;91(16):7673-7
FCE 27164
154755-58-5 1,3,5-
Naphthalenetrisulfonic acid, 7,7'-
(carbonylbis(imino(1-
methyl-
1H-
pyrrole-
4,2-
diyl)carbonylimino(1-
methyl-
1H-
pyrrole-
4,2-
diyl)carbonylimino))bis-
, hexasodium salt
*Distamycins.
Biochem Pharmacol 1994 Jan 20;47(2):295-302
FCE 26644
0
*Distamycins.
Biochem Pharmacol 1994 Jan 20;47(2):295-302
tren-
microgonotropen-
b
155056-06-7
*Distamycins.
Proc Natl Acd Sci U S A Nov 1;90(12):10018-22
dien-
microgonotropen-
c
142155-06-4
*Distamycins.
Proc Natl Acad Sci U S A 1993 Nov 1;90(21):10018-22
Distel
144236-70-4 1H-
Pyrrole-
2-
carboxamide, 4-
(((4-
(formylamino)-
1-
methyl-
1H-
pyrrol-
2-
yl)carbonyl)amino)-
N-
(5-
(((3-
((9-
methoxy-
5,11-
dimethyl-
6H-
pyrido(4,3-
b)carbazol-
1-
yl)amino)propyl)amino)carbonyl)-
1-
methyl-
1H-
pyrrol-
3-
yl)-
1-
methyl
*Distamycins
*Ellipticines
Deoxyribonuclease I/antagonists & inhibitors.
Biochemistry 1992 Dec 15;31(49):12385-96
FCE 24561
145875-38-3
*Distamycins.
Toxicology 1992 Nov 15;75(3):209-19
thioformyldistamycin
139341-61-0
*Distamycins.
J Biomol Struct Dyn 1991 Dec;9(3):599-611
tallimustine
115308-98-0 1H-
Pyrrole-
2-
carboxamide, N-
(5-
(((3-
amino-
3-
iminopropyl)amino)carbonyl)-
1-
methyl-
1H-
pyrrol-
3-
yl)-
4-
(((4-
((4-
(bis(2-
chloroethyl)amino)benzoyl)amino)-
1-
methyl-
1H-
pyrrol-
2-
yl)carbonyl)amino)-
1-
methyl
*Distamycins
*Nitrogen Mustard Compounds.
Pharma Action
Antineoplastic Agents
;
Antineoplastic Agents, Alkylating
Cancer Res 1991;51(1):199
distamycin-
DAPI
0
*Distamycins
*Indoles.
Cytogenet Cell Genet 1988;47(4):192
distamin
65361-29-7 1H-
Pyrrole-
2-
carboxamide, N-
(5-
(((3-
(dimethylamino)propyl)amino)carbonyl)-
1-
methyl-
1H-
pyrrol-
3-
yl)-
4-
(((4-
(formylamino)-
1-
methyl-
1H-
pyrrol-
2-
yl)carbonyl)amino)-
1-
methyl
*Distamycins.
Biofizika 1986;31(5):768
M-
bromoacetyldistamycin
99328-13-9
*Distamycins.
Ann NY Acad Sci 1986;471:51
distamycin-
EDTA-
iron(II)
0
*Distamycins
*Edetic Acid
*Organometallic Compounds
Iron.
Life Sci 1983;32(26):2915
stallimycin
636-47-5
*Distamycins.
Pharma Action
Antiviral Agents
Mol Biol (Mosk) 1980;14(1):94
permethyldistamycin A
75792-61-9 1H-
Pyrrole-
2-
carboxamide, N-
(5-
(((3-
amino-
3-
iminopropyl)amino)carbonyl)-
1,2,4-
trimethyl-
1H-
pyrrol-
3-
yl)-
4-
(((4-
(4-
formylamino)-
1,3,5-
trimethyl-
1H-
pyrrol-
2-
yl)carbonyl)amino)-
1,3,5-
trimethyl-
, monohydrochloride
*Distamycins.
J Med Chem 1981;24(1):33