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Dioxygenases

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Definition: Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.     
Examples Catechol 1,2-Dioxygenase; Catechol 2,3-Dioxygenase; Cysteine Dioxygenase; Homogentisate 1,2-Dioxygenase; 3-Hydroxyanthranilate 3,4-Dioxygenase; 4-Hydroxyphenylpyruvate Dioxygenase; Indoleamine-Pyrrole 2,3,-Dioxygenase; Jumonji Domain-Containing Histone Demethylases; Lipoxygenases; Protocatechuate-3,4-Dioxygenase; Tryptophan Oxygenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ALKBH8 protein, Arabidopsis  EC 1.13.11.-   *Arabidopsis Proteins *Dioxygenases. Nucleic Acids Res. 2011 Sep 1;39(17):7688-701
ALKBH5 protein, human  EC 1.14.11.-   *Membrane Proteins *Dioxygenases. PLoS One 2011;6(1):e16210
HIF prolyl hydroxylase, rat  EC 1.14.11.2   *Dioxygenases. J Neurochem. 2010 Oct;115(1):209-19
o-xylene dioxygenase, Rhodococcus  EC 1.13.11.-   *Bacterial Proteins *Dioxygenases. Appl Microbiol Biotechnol. 2010 May;86(6):1841-7
ETHE1 protein, mouse  EC 1.13.11.18   *Mitochondrial Proteins *Dioxygenases. Nat Med 2009 Feb;15(2):200-5
At2g25450 protein, Arabidopsis  EC 1.14.99.-   *Dioxygenases *Arabidopsis Proteins. Plant Physiol 2008 Dec;148(4):2096-108
hydroxymandelate synthase, Amycolatopsis orientalis  EC 1.13.11.-   *Dioxygenases. Biochemistry 2008 Feb 19;47(7):2002-13
2'-aminobiphenyl-2,3-diol-1,2-dioxygenase, Pseudomonas stutzeri  EC 1.13.11.-   *Dioxygenases. Cell Biochem Biophys 2006;44(3):530-8
salicylate 1,2-dioxygenase, Pseudaminobacter salicylatoxidans  EC 1.13.11.-   *Dioxygenases. Acta Crystallograph Sect F Struct Biol Cryst Commun 2006 Jun 1;62(Pt 6):553-5
ABH3 protein, mouse  EC 1.14.11.-   *DNA Repair Enzymes *Dioxygenases. EMBO J 2006 May 17;25(10):2189-98
Alkbh2 protein, mouse  EC 1.14.11.-   *DNA Repair Enzymes *Dioxygenases. EMBO J 2006 May 17;25(10):2189-98
ADI1 protein, S cerevisiae  EC 1.13.11.-   *Saccharomyces cerevisiae Proteins *Dioxygenases. J Biol Chem 2005 Aug 12;280(32):28997-9003
xanthine dioxygenase, Aspergillus nidulans  EC 1.14.11.-   *Fungal Proteins *Dioxygenases. Mol Microbiol 2005 Jul;57(1):276-90
indole dioxygenase idoA, Pseudomonas alcaligenes  EC 1.13.11.17   *Dioxygenases. FEMS Microbiol Lett 2004 Oct 15;239(2):285-93
CCD8 protein, Arabidopsis  EC 1.13.11.-   *Arabidopsis Proteins *Dioxygenases. J Biol Chem 2004 Nov 5;279(45):46940-5
CCD7 protein, Arabidopsis  EC 1.13.11.-   *Dioxygenases. J Biol Chem 2004 Nov 5;279(45):46940-5
EGLN3 protein, human  EC 1.14.11.2   *Dioxygenases. FEBS Lett 2004 Jul 16;570(1-3):166-70
ALKBH2 protein, human  0   *DNA Repair Enzymes *Dioxygenases DNA Repair. Nucleic Acids Res 2004;32(4):1548-54
ALKBH3 protein, human  EC 1.14.11.-   *Dioxygenases *DNA Repair Enzymes DNA Repair. Nucleic Acids Res 2004;32(4):1548-54
ADI1 protein, human  EC 1.-   *Dioxygenases. J Biol Chem 2004 Mar 26;279(13):12734-43
Adi1 protein, rat  EC 1.13.11.-   *Dioxygenases. Endocrinology 2004 Apr;145(4):1933-42
sulfur dioxygenase  EC 1.13.11.18   *Dioxygenases. Microbiology 2003 Jul;149(Pt 7):1699-709
EGLN2 protein, human  EC 1.14.11.-   *Nuclear Proteins *Dioxygenases. Oncogene 2002 Jan 24;21(5):836-43
carotenoid cleavage dioxygenase 1  EC 1.13.11.-   *Dioxygenases. J Biol Chem 2001 Jul 6;276(27):25208-11
dibenzofuran 4,4a-dioxygenase  EC 1.13.11.-   *Dioxygenases. Biochem Biophys Res Commun 2001 Apr 27;283(1):195-204
2,4'-dihydroxyacetophenone dioxygenase  EC 1.13.11.41   *Dioxygenases. Biochem J 1999 Dec 1;344( Pt 2):397-402
JLP1 protein, S cerevisiae  EC 1.14.11.-   *Saccharomyces cerevisiae Proteins *Dioxygenases. J Bacteriol 1999 Sep;181(18):5876-9
flavonol 2,4-dioxygenase  EC 1.13.11.-   *Dioxygenases Copper Glycoproteins Flavonols.
2,6-dichlorohydroquinone dioxygenase  EC 1.13.-   *Dioxygenases. Biochemistry 1999 Jun 15;38(24):7659-69
DitA protein, Pseudomonas abietaniphila  EC 1.13.11.-   *Ferredoxins *Dioxygenases. J Bacteriol 1999 May;181(9):2675-82
1-hydroxy-2-naphthoate dioxygenase  EC 1.13.11.-   *Dioxygenases. J Biol Chem 1998 Apr 3;273(14):8332-6
9-cis-epoxy-carotenoid dioxygenase  EC 1.13.11.51   *Plant Proteins *Dioxygenases Chloroplasts Arabidopsis Proteins. Proc Natl Acad Sci U S A 1997 Oct 28;94(22):12235-40
carbazole 1,9a-dioxygenase  EC 1.13.11.-   *Bacterial Proteins *Dioxygenases. J Bacteriol 1997 Aug;179(15):4850-8
2-aminophenol 1,6-dioxygenase  EC 1.13.-   *Dioxygenases. J Biol Chem 1997 Jun 6;272(23):14727-32
1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (decyclizing, CO-forming)  EC 1.13.11.-   *Dioxygenases. Eur J Biochem 1996 Sep 15;240(3):576-83
1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase (decyclizing, CO-forming)  EC 1.13.11.-   *Dioxygenases. Eur J Biochem 1996 Sep 15;240(3):576-83
YHB1 protein, S cerevisiae  EC 1.14.12.17   *Hemeproteins *Saccharomyces cerevisiae Proteins *Dioxygenases. Proc Natl Acad Sci U S A 1992 Jun 1;89(11):5015-9
6-chlorohydroxyquinol 1,2-dioxygenase  EC 1.13.11.-   *Dioxygenases. J Bacteriol 1995 Jan;177(1):229-34
pahA protein, Pseudomonas putida  EC 1.13.11.-   *Bacterial Proteins *Dioxygenases. J Bacteriol 1994 Apr;176(8):2444-9
3-chlorobenzoate-3,4-(4,5)-dioxygenase  EC 1.14.-   *Dioxygenases Alcaligenes. Appl Environ Microbiol 1993 Nov;59(11):3625-33
2,2',3-trihydroxybiphenyl dioxygenase  EC 1.13.11.-   *Dioxygenases. J Bacteriol 1993 Nov;175(22):7313-20
aci-reductone oxidase (CO-forming)  EC 1.13.11.-   *Dioxygenases. J Biol Chem 1993 Oct 15;268(29):21466-9
3-carboxyethylcatechol 2,3-dioxygenase  EC 1.13.11.16   *Dioxygenases. Biochim Biophys Acta 1993 Oct 6;1202(2):258-64
3,5-dichlorocatechol 1,2-dioxygenase  EC 1.13.11.-   *Dioxygenases. Arch Biochem Biophys 1993 Feb 1;300(2):738-46
2,3-dihydroxy-4-cumate-3,4-dioxygenase  EC 1.13.11.-   *Dioxygenases. Biochem Int 1992 Oct;28(1):97-103
2,3-dihydroxybiphenyl oxygenase  EC 1.13.11.39   *Dioxygenases. J Bacteriol 1983;154(3):1356
5-aminosalicylic acid 1,2-dioxygenase  EC 1.13.11.-   *Dioxygenases. Biochem J 1992 Mar 15;282(Pt 3):675-80
3,4-dihydroxyxanthone dioxygenase  EC 1.13.11.-   *Dioxygenases Xanthones. Appl Environ Microbiol 1991;57(8):2217
chlorobenzene dioxygenase  EC 1.13.99.-   *Dioxygenases. J Bacteriol 1991;173(22):7077
lignostilbene-alpha,beta-dioxygenase  EC 1.13.11.-   *Dioxygenases. Agric Biol Chem 1991;55(5):1411
4-sulfobenzoate 3,4-dioxygenase  EC 1.14.12.-   *Dioxygenases. Biochem J 1991;274(Pt 3):833
protocatechuate 2,3-dioxygenase  EC 1.13.11.-   *Dioxygenases. Methods Enzymol 1990;188:95
3-phenylcatechol dioxygenase  EC 1.13.11.-   *Dioxygenases. Appl Environ Microbiol 1988;54(11):2664
3-methylcatechol 2,3-dioxygenase  EC 1.13.11.-   *Dioxygenases. Appl Environ Microbiol 1988;54(6):1498
catechol oxygenase II  EC 1.13.11.-   *Dioxygenases. Proc Natl Acad Sci USA 1987;84(13):4460
(4-hydroxybenzoyl)methanol dioxygenase  EC 1.13.11.-   *Dioxygenases. Biochem J 1986;239(2):469
isopropylbenzene dioxygenase  EC 1.13.11.-   *Dioxygenases. J Bacteriol 1986;168(1):123
chlorocatechol 1,2-dioxygenase  EC 1.13.11.-   *Dioxygenases Bacterial Proteins. J Bacteriol 1985;161(1):85
4-chlorophenylacetate 3,4-dioxygenase  EC 1.13.11.-   *Dioxygenases. J Bacteriol 1984;160(2):618
hydroxyquinol 1,2-dioxygenase  EC 1.13.11.-   *Dioxygenases. J Bacteriol 1984;159(1):353
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