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Vitamin B 12

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Definition: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.  therapeutic use: coordinate disease with /drug ther, not /diet ther   
Pharmacological Action Vitamin B Complex
See Also Schilling Test
Examples Cobamides; Hydroxocobalamin 		Other names Cyanocobalamin; Cobalamin; B12, Vitamin; B 12, Vitamin; Vitamin B12; Eritron; CobalaminsDrugs* : REDISOL; DEPINAR; RUBRATOPE-60; VIBISONE; BERUBIGEN; DICOPAC KIT; RUVITE; RUBIVITE; RUBRATOPE-57 KIT; COBAVITE; RUBRAMIN PC; VI-TWEL; BETALIN 12; RUBRATOPE-57; RUBRATOPE-60 KIT; NASCOBAL; CYANOCOBALAMIN CO 57 SCHILLING TEST KIT; CALOMIST; CYANOCOBALAMIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Co beta-cyano-5'',6''-dimethylbenzimidazolyl-176-isocobamide  0   Vitamin B 12/*analogs & derivatives. Chemistry. 2010 Sep 24;16(36):10984-8
butylcobalamin  0   Vitamin B 12/*analogs & derivatives. Chemistry. 2010 Jun 18;16(23):6615-22
B12-(BQBA(Re(CO)3))  0   *Organometallic Compounds Vitamin B 12/*analogs & derivatives Rhenium. J Med Chem. 2009 Aug 27;52(16):5253-61
AFA-B12  0   *Vitamin B 12 Dietary Supplements. Int J Vitam Nutr Res. 2009 Mar;79(2):117-23
butaphosphan, cyanocobalamin drug combination  0   *Organophosphorus Compounds Drug Combinations Vitamin B 12.
Pharma Action Micronutrients
Gd-TTHA-CNCbl  0   *Organometallic Compounds *Vitamin B 12. Chemistry. 2009 Aug 10;15(32):7980-9
Gd-DTPA-CNCbl  0   *Vitamin B 12 Gadolinium DTPA/*analogs & derivatives. Chemistry. 2009 Aug 10;15(32):7980-9
sclerovit  0   *Vitamin E *Folic Acid *Vitamin B 12 *Vitamin B 6 Drug Combinations. Clin Hemorheol Microcirc 2009;42(1):19-28
3'-deoxy-2',3'-anhydrothymidylcobalamin  0   Thymidine/*analogs & derivatives Vitamin B 12/*analogs & derivatives. Dalton Trans 2007 Jun 14;(22):2336-42
2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin  0   Vitamin B 12/*analogs & derivatives. Dalton Trans 2006 Nov 28;(44):5269-77
N-acetylcysteinylcobalamin  0   Cysteine/*analogs & derivatives Vitamin B 12/*analogs & derivatives. Dalton Trans 2006 Nov 28;(44):5269-77
homocysteinylcobalamin  0   Homocysteine/*analogs & derivatives Vitamin B 12/*analogs & derivatives. Dalton Trans 2006 Nov 28;(44):5269-77
CBC 244  0   *Rhodamines Vitamin B 12/*analogs & derivatives. FEBS J 2006 Oct;273(20):4742-53
vitamin B12-modified dextran-g-polyethylene oxide cetyl ether  0   *Glucans Vitamin B 12/*analogs & derivatives. Biomacromolecules 2005 Sep-Oct;6(5):2462-7
thioretinaco  0   Homocysteine/*analogs & derivatives Vitamin B 12/*analogs & derivatives. Res Commun Mol Pathol Pharmacol 2002;111(5-6):179-98
beta-neopentylcobalamin  0   Vitamin B 12/*analogs & derivatives. Inorg Chem 2003 Aug 11;42(16):4849-56
chlorovinylcobalamin  0   *Vinyl Compounds Vitamin B 12/*analogs & derivatives. J Am Chem Soc. 2003 Apr 16;125(15):4410-1
n-propylcobalamin  0   Vitamin B 12/*analogs & derivatives Vitamin B 12. J Am Chem Soc 2002 Jan 23;124(3):434-41
ethylcobalamin  0   Vitamin B 12/*analogs & derivatives Vitamin B 12. J Am Chem Soc 2002 Jan 23;124(3):434-41
factor A  0   Vitamin B 12/*analogs & derivatives. J Bacteriol 2000 Sep;182(17):4773-82
cyclohexylthiocobalamin  0   Vitamin B 12/*analogs & derivatives. J Inorg Biochem 1999 Sep 30;76(3-4):197-209
nitrosylcobalamin  0   *Nitroso Compounds Vitamin B 12/*analogs & derivatives. Anticancer Drugs 1998 Mar;9(3):239-44
cob(II)alamin  14463-33-3   Vitamin B 12/*analogs & derivatives. Science 1996 Jan 26;271(5248):477-81
2',5'-dideoxyadenosylcobalamin  14220-72-5   Vitamin B 12/*analogs & derivatives. Biochemistry 1995 Oct 31;34(43):14125-30
nitritocobalamin  20623-13-6   Vitamin B 12/*analogs & derivatives. J Chromatogr B Biomed Appl 1994 Oct 3;660(1):180-5
cysteinylcobalamin  60659-91-8 Cobinamide, Co-(L-cysteine-S) deriv., dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole  *Vitamin B 12. Biochemistry 1994 May 24;33(20):6310-5
proheparum  72980-85-9   *Cysteine *Inositol *Liver Extracts *Bis-Trimethylammonium Compounds *Vitamin B 12 Drug Combinations. Nippon Shokakibyo Gakkai Zasshi 1993 Nov;90(11):2945-50
CobC protein, Bacteria  132052-17-6   *Transaminases *Bacterial Proteins Transaminases Vitamin B 12/biosynthesis. Eur J Biochem. 1993 Jan 15;211(1-2):373-6
hydroxycobalamin(c-lactam)  0   Vitamin B 12/*analogs & derivatives. J Biol Chem 1991 Nov 5;266(31):20998-1003
cobinamide phosphate guanylyltransferase  EC 2.7.7.-   *Nucleotidyltransferases Multienzyme Complexes Vitamin B 12. J Bacteriol 1991;173(19):6052
cobinamide kinase  EC 2.7.1.-   *Phosphotransferases (Alcohol Group Acceptor) Vitamin B 12. J Bacteriol 1991;173(19):6052
glutathionylcobalamin  129128-04-7   Glutathione/*analogs & derivatives Vitamin B 12/*analogs & derivatives. Biochem Biophys Res Commun 1990;169(2):443
N-homocysteine thiolactonyl retinamido cobalamin  0   Homocysteine/*analogs & derivatives Vitamin B 12/*analogs & derivatives. Res Comm Chem Pathol Pharmacol 1989;66(1):117
cyanocobalamin-e-monocarboxylic acid  26264-28-8   Vitamin B 12/*analogs & derivatives. Biochemistry 1989;28(18):7213
cyanocobalamin-b-monocarboxylic acid  38218-77-8   Vitamin B 12/*analogs & derivatives. Biochemistry 1989;28(18):7213
adeninylethylcobalamin  59209-78-8 Cobinamide, Co-(2-(6-amino-9H-purin-9-yl)ethyl) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole  Adenine/*analogs & derivatives Vitamin B 12/*analogs & derivatives. J Biol Chem 1987;262(18):8544
factor III, vitamin B 12  14708-95-3   Vitamin B 12/*analogs & derivatives. Eur J Biochem 1987;162(2):275
hepahydryl  0   *Amino Acids *Nucleic Acids *Vitamin B 12 Drug Combinations. Radiobiol Radiother (Berl) 1986;27(4):451
cyanocobalamin, pyridoxine, thiamine drug combination  0   *Pyridoxine *Thiamine *Vitamin B 12 Drug Combinations. Acta Vitaminol Enzymol 1985;7(1-2):9
BtuB protein, E coli  0   *Bacterial Outer Membrane Proteins *Membrane Transport Proteins *Escherichia coli Proteins Bacterial Outer Membrane Proteins Vitamin B 12. J Bacteriol 1985;161(3):896
aquacobalamin  13422-52-1   Vitamin B 12/*analogs & derivatives. Biochemistry 1984;23(23):5653
Co-(carboxymethyl)cobalamin  14517-61-4   Vitamin B 12/*analogs & derivatives. Biochemistry 1984;23(23):5653
FV 82  88154-94-3   *Tylosin *Iron-Dextran Complex *Pyridoxine *Vitamin B 12 Drug Combinations. Vet Med Nauki 1983;20(3-4):40
intrinsic factor-vitamin B12 complex releasing factor, rat  0   *Glycoproteins Intrinsic Factor Vitamin B 12. Biochim Biophys Acta 1982;719(3):619
intrinsic factor-vitamin B 12 complex  0   *Intrinsic Factor *Vitamin B 12. Biochim Biophys Acta 1982;719(3):619
aminopyrine, dexamethasone, phenylbutazone, thiamine, vitamin B12 drug combination  84020-72-4 Vitamin B12, mixt. with 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride, 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one and (11beta,16alpha)-9-flu  *Aminopyrine *Dexamethasone *Phenylbutazone *Thiamine *Vitamin B 12 Drug Combinations.
Pharma Action Vitamins 		Arzneimittelforsch 1982;32(11):1489
methylcobalamine chlorpalladate  58220-71-6 Palladate(1-), trichloro(cobinamide Co-methyl deriv., hydroxide, monohydrate, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole)  *Organometallic Compounds Vitamin B 12/*analogs & derivatives Palladium. Biull Eksp Med Biol 1981;91(1):57
triredisol  76773-81-4 Vitamin B12, mixt. with 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride and 5-hydroxy-6-methyl-3,4-pyridinedimethanol  *Pyridoxine *Thiamine *Vitamin B 12 Drug Combinations. Indian Heart J 1980;32(4):244
compound 102804  63278-43-3 Compound 102804, from Bacillus cereus  *Vitamin B 12. Biochem Biophys Res Comm 76(2):420;1977; J Antibiotics 30(4):283;1977
aminopropylcobalamin  72728-11-1 Cobinamide, Co-(3-aminopropyl) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole  Vitamin B 12/*analogs & derivatives. Blood 55(1):160;1980
mecobalamin  13422-55-4 cobinamide, Co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole  Vitamin B 12/*analogs & derivatives. Am J Nutr 1980;33(1):1; Biochim Biophys Acta 571(1):81; Bioinorg Chem 8:1;1978; Biokhimiia 38(3):507;1973; Biull Eksp Biol Med 1980;89(2):185; Mikrobiologiia 48(2):217;1979; Pobl Gematol Pereliv Krovi 3(3):26;1978; Prikl Biokhim Mikrobiol 1979;15(5):719; Vestn Akad Med Nauk SSSR (1):72;1979
ferribalamin  69743-59-5 Ferribinamide, cyanide hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole  Vitamin B 12/*analogs & derivatives. FEBS Lett 97(2):325;1979
propiovit  78515-85-2   *Vitamin B 12 *Complex Mixtures Vitamins. Veterinariia (6):79;1978
vitamin B12 tyrosine methyl ester  0   Vitamin B 12/*analogs & derivatives. Clin Chem 24(3):460;1978
vitamin B12 factor B  13963-62-7 cobinamide, cyanide hydroxide, monohydrate  Vitamin B 12/*analogs & derivatives. J Anim Sci 46(1):304;1978
sulfitocobalamin  15671-27-9   *Vitamin B 12. Am J Clin Nutr 31(5):739;1978; J Chromatogr 1979;177(2):360; Prep Biochem 8(6):411;1978
choline, dehydrocholic acid, magnesium orotate, orotic acid, Vitamin B12 drug combination  77648-60-3 Vitamin B12, mixt. with (T-4)-bis(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylato-N3,O4)magnesium, 2-hydroxy-N,N,N-trimethylethanaminium salt with 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid (1:1) and 3,7,12-Trioxocholanic acid  *Choline *Dehydrocholic Acid *Orotic Acid *Vitamin B 12 Drug Combinations.
Pharma Action Vitamins 		Med Monatschr 31(11):524;1977
formylmethylcobalamin  41871-63-0 Cobinamide, Co-(2-oxoethyl) deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole  *Vitamin B 12. JBC 252(14):5004;1977
cobyric acid  14708-92-0   Vitamin B 12/*analogs & derivatives. Arch Biochem Biophys 175(1):121;1976
Dimaestad plus  0   *Adenosine Monophosphate *Deanol *Methionine *Vitamin B 12 Drug Combinations. Therap Gegenwart 114(10):1701;1975
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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