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Hydroxyquinolines

More information in Books or onNLM PubMed
Definition: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.     
Examples Decoquinate; Kynurenic Acid; Oxamniquine; Oxyquinoline; Procaterol 		Other names Chiniofon; Quinolinols
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BAY 60-5521  0   *Hydroxyquinolines Cholesterol Ester Transfer Proteins/antagonists & inhibitors. Br J Clin Pharmacol. 2012 Feb;73(2):210-8.
5-hydroxy-6-methoxy-2-(3',4',5'-trimethoxybenzoyl)quinoline  0   *Hydroxyquinolines. J Med Chem. 2011 Dec 22;54(24):8517-25.
((1-ethylpyrrolidin-2-yl) methyl)-4-hydroxy-7-methoxy-quinoline-3-carboxamide  0   *Hydroxyquinolines. Int Immunopharmacol 2011 Apr;11(4):435-43
JLK 1486  0   *Hydroxyquinolines. Int J Oncol 2010 Dec;37(6):1463-70
6-hydroxy-9-methoxy-11H-indeno(1,2-c)quinolin-11-one O-2-(pyrrolidin-1-yl)ethyl oxime  0   *Hydroxyquinolines *Oximes. J Med Chem 2010 Aug 26;53(16):6164-79
7-hydroxyquinoline  0   *Hydroxyquinolines. Photochem Photobiol Sci. 2009 Nov;8(11):1611-7
2,3-dihydroxyquinoline-4-O-glucopyranoside  0   *Glucosides *Hydroxyquinolines. Yao Xue Xue Bao 2008 Nov;43(11):1116-8
1,2-dihydro-2-amino-5,7-dihydroxy-3-methylimidazo(4,5-f)quinoline  0   *Hydroxyquinolines *Imidazoles. J Mass Spectrom 2009 Sep;44(9):1359-68
1,2-dihydro-2-amino-5-O-glucuronide-3-methylimidazo(4,5-f)quinoline  0   *Hydroxyquinolines *Glucuronides. J Mass Spectrom 2009 Sep;44(9):1359-68
1,2-dihydro-2-amino-5-hydroxy-3-methylimidazo(4,5-f)quinoline  0   *Hydroxyquinolines *Imidazoles. J Mass Spectrom 2009 Sep;44(9):1359-68
5-amino-6-hydroxy-8H-benzo(6,7)azepino(5,4,3-de)quinolin-7-one  0   *Benzazepines *Hydroxyquinolines. Chem Res Toxicol 2009 Sep;22(9):1588-93
7-(phenyl(8-quinolinylamino)methyl)-8-quinolinol  0   *Aminoquinolines *Hydroxyquinolines. Arch Biochem Biophys 2009 Nov;491(1-2):75-84
1-butyl-7-chloro-6-hydroxytetrahydroquinoline  0   *Hydroxyquinolines. Bioorg Med Chem 2009 Jul 15;17(14):4968-80
NSC 84093  0   *Aniline Compounds *Hydroxyquinolines. Chem Biol 2009 Jan 30;16(1):93-104
3-(3-carboxybenzyl)-1-((6-ethylbenzo(d)(1,3)dioxol-5-yl)methyl)-6-hydroxy-4-oxo-1,4-dihydroquinoline-2-carboxylic acid  0   *Hydroxyquinolines. Can J Physiol Pharmacol 2008 Aug;86(8):571-5
5-amino-8-hydroxyquinoline  0   *Hydroxyquinolines. Anal Sci. 2008 Feb;24(2):219-23
PSI-421  0   *Hydroxyquinolines. Thromb Haemost 2008 Feb;99(2):343-51
zinc(II)-bis(8-hydroxyquinoline)  0   *Hydroxyquinolines *Organometallic Compounds Zinc. J Phys Chem B 2007 May 24;111(20):5767-72
8-hydroxy-7-quinolinecarboxaldehyde  0   *Hydroxyquinolines. Spectrochim Acta A Mol Biomol Spectrosc 2006 Dec;65(5):1197-207
5-(N-methyl-N-propargylaminomethyl)-8-hydroxyquinoline  0   *Hydroxyquinolines. J Neurochem 2007 Jan;100(2):490-502
2-(4-chlorophenyl)-3-hydroxy-8-phenylquinoline-4-carboxylic acid  0   *Hydroxyquinolines P-Selectin. J Med Chem 2007 Jan 11;50(1):21-39
beta-isocupreidine  0   *Hydroxyquinolines *Quinuclidines. Org Lett 2006 Nov 9;8(23):5357-60
2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo(H)quinoline-4-carboxylic acid  0   *Hydroxyquinolines P-Selectin. J Vasc Surg 2006 Sep;44(3):625-32
7-(anilino(phenyl)methyl)-2-methyl-8-quinolinol  0   *Aniline Compounds *Hydroxyquinolines. J Med Chem 2006 Jun 29;49(13):3759-62
5-nitroso-8-quinolinol  0   *Hydroxyquinolines *Nitroso Compounds Histone Deacetylases/antagonists & inhibitors. J Pharmacol Exp Ther 2006 May;317(2):546-52
bis(8-hydroxyquinoline-2-carbaldehyde)-N,N'-cyclohexane-1,2-diamine  0   *Cyclohexylamines *Hydroxyquinolines. Biochem Pharmacol 2005 Dec 19;71(1-2):214-22
bis(8-hydroxyquinoline-2-carbaldehyde)-N,N'-ethylenediamine  0   *Ethylenediamines *Hydroxyquinolines. Biochem Pharmacol 2005 Dec 19;71(1-2):214-22
3-(8-hydroxyquinolin-5-yl)alanine  0   *Hydroxyquinolines Alanine/*analogs & derivatives. Biochem Pharmacol 2005 Nov 25;70(11):1642-52
M32 compound  0   *Hydroxyquinolines Cysteine/*analogs & derivatives Monoamine Oxidase/antagonists & inhibitors. J Neurochem 2005 Oct;95(1):68-78
HLA20 compound  0   *Hydroxyquinolines *Piperazines Monoamine Oxidase/antagonists & inhibitors. J Neurochem 2005 Oct;95(1):68-78
7-(5'-(3'-phenylisoxazolino)methyl)-8-hydroxyquinoline  0   *Hydroxyquinolines. Farmaco. 2004 Mar;59(3):195-9
ruprechstyril  0   *Hydroxyquinolines. J Nat Prod 2003 Aug;66(8);1065-9
5-(p-aminophenylazo)-8-hydroxyquinoline  0   *Azo Compounds *Hydroxyquinolines. Boll Chim Farm 2002 Jul-Aug;141(4):274-8
L 703717  0   *Hydroxyquinolines *Quinolones Carbon Radioisotopes Ligands. Nucl Med Biol 1999 Feb;26(2):245-7
5,8-dimethoxy-3-hydroxy-4-quinolone  0   *Hydroxyquinolines *Quinolones. Bioorg Med Chem Lett 1999 Feb 8;9(3):543-6
7-morpholinomethyl-8-hydroxyquinoline  0   *Hydroxyquinolines *Morpholines. Life Sci 1999;64(9):813-25
3-O-methylviridicatin  0   *Hydroxyquinolines *Quinolones. Antivir Chem Chemother 1998 Mar;9(2):149-55
8-hydroxy-5-(1-hydroxy--2-(N-(2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)carbostyril glucuronide  0   *Glucuronates *Hydroxyquinolines. J Pharm Biomed Anal 1998 Jun;17(2):245-54
viridicatol  14484-44-7   *Hydroxyquinolines *Quinolones. Antonie Van Leeuwenhoek 1997 Aug;72(2):119-26
2-hydroxyquinoline  59-31-4   *Hydroxyquinolines. Farmaco 1997 Mar;52(3):199-203
methyl-6-decyloxy-7-isoproxy-4-hydroxyquinoline-3-carboxylate  0   *Hydroxyquinolines. Int J Parasitol 1997 Jan;27(1):101-11
8-hydroxyquinoline-beta-galactoside  0   *Galactosides *Hydroxyquinolines. Appl Environ Microbiol 1996 Oct;62(10):3868-70
buquinolate  5486-03-3   *Hydroxyquinolines.
ferric 8-hydroxyquinoline  0   *Ferric Compounds *Hydroxyquinolines. Photochem Photobiol 1995 Sep;62(3):528-34
trensox  0   *Ethylamines *Hydroxyquinolines. Biochem J 1995 Dec 15;312(Pt 3):879-85
4-hydroxyquinoline-3-aminoacetic acid  158619-69-3   *Hydroxyquinolines. FEBS Lett 1994 Jul 25;349(1):39-44
8-(4-tolylsulfinyl)-2,3,4,4a,5,6,7,8-octahydro-4a-quinolinol  154325-32-3   *Hydroxyquinolines *Tosyl Compounds. Acta Crystallogr C 1994 Mar 15;50(Pt 3):425-8
2-chloro-7,8-dihydro-7,8-dihydroxyquinoline  151262-67-8   *Hydroxyquinolines. FEMS Microbiol Lett 1993 Sep 1;112(2):151-8
3-fluoro-5,6-dihydroquinoline 5,6-diol  148324-56-5   *Hydroxyquinolines. Biol Pharm Bull 1993 Mar;16(3):232-4
carmoterol  147568-66-9 8-Hydroxy-5-((1R)-1-hydroxy-2-(((2R)-2-(4- methoxyphenyl)propan-2-yl)amino)ethyl)quinolin-2(1H)-one  *Amphetamines *Hydroxyquinolines. Jpn J Pharmacol 1991 Oct;57(2):175-85
6-hydroxyquinoline  580-16-5   *Hydroxyquinolines. Biol Chem Hoppe Seyler 1991;372(6):381
6-methoxy-N-ethyl-1,2-dihydroquinoline  134907-09-8   *Hydroxyquinolines. Biochemistry 1991;30(32):7879
4-acetoxy-6-decyloxy-7-isopropoxy-3-methoxycarbonylquinoline  80061-37-6   *Hydroxyquinolines. Trans R Soc Trop Med Hyg 1990;84(6):759
6-butyl-4-hydroxy-3-methoxycarbonyl-7-beta-phenoxyethoxyquinoline  19828-70-7 3-Quinolinecarboxylic acid, 6-butyl-4-hydroxy-7-(2-phenoxyethoxy)-, methyl ester  *Hydroxyquinolines. Trans R Soc Trop Med Hyg 1990;84(6):759
3-heptyl-4-hydroxy-7-methoxy-2-methylquinoline  4939-34-8   *Hydroxyquinolines. Trans R Soc Trop Med Hyg 1990;84(6):759
luzopeptin-DNA complex  0   *DNA *Hydroxyquinolines. Biochemistry 1991;30(16):4026
SK&F 96079  122456-25-1   *Hydroxyquinolines H(+)-K(+)-Exchanging ATPase/antagonists & inhibitors. Biochim Biophys Acta 1990;1029(1):24
2-(6-hydroxyquinolyl)-2-thiazole-4-carboxylic acid  122364-83-4 4-Thiazolecarboxylic acid, 4,5-dihydro-2-(6-hydroxy-2-quinolinyl)-, (S)  *Hydroxyquinolines *Thiazoles Luminescent Agents. Photochem Photobiol 1989;49(5):689
2-amino-3-methylimidazo(4,5-f)-quinoline 5-sulfate ester  122719-40-8   *Hydroxyquinolines. Cancer Res 1989;49(16):4407
5-hydroxy-2-amino-3-methylimidazo(4,5-f)quinoline  122719-38-4   *Hydroxyquinolines. Cancer Res 1989;49(16):4407
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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