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Mitomycins

More information in Books or onNLM PubMed
Definition: A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.  MITOMYCIN is also available   
Pharmacological Action Antibiotics, Antineoplastic
Examples Mitomycin; Porfiromycin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-N,7'-N'-(1',2'-dithiocanyl-3',8'-dimethylenyl)bismitomycin C  0   *Disulfides *Mitomycins. Bioorg Med Chem 2011 Jul 1;19(13):4004-13
2,3-(distearoyloxy)propane-1-dithio-4'-benzyloxycarbonyl-mitomycin C  0   *Mitomycins. Clin Cancer Res 2006 Mar 15;12(6):1913-20
7-N,7'-N'-(1',2'-dithianyl-3',6'-dimethylenyl)bismitomycin C  0   *Mitomycins. Org Biomol Chem. 2005 Feb 7;3(3):471-82
mitosane  0   *Mitomycins. Org Lett 2001 Sep 6;3(18):2879-82
7-N-(mercaptoethyl)mitomycin C  0   *Mitomycins *Sulfhydryl Compounds. J Med Chem 1999 Mar 11;42(5):788-90
1a-docosahexaenoyl mitomycin C  0   *Docosahexaenoic Acids *Mitomycins Protein-Tyrosine Kinases/antagonists & inhibitors. Biochem Biophys Res Commun 1998 Jul 30;248(3):858-63
1a-(4-(3-hydroxy-1,3,5(10)-estratrien-17-yloxycarbonyl)butyryl)mitomycin C  0   *Mitomycins Estradiol/*analogs & derivatives. Biol Pharm Bull 1997 Oct;20(10):1096-102
1a-(4-(3-benzoyloxy-1,3,5(10)-estratrien-17-yloxycarbonyl)butyryl)mitomycin C  0   *Mitomycins Estradiol/*analogs & derivatives. Biol Pharm Bull 1997 Oct;20(10):1096-102
mitomycin D  10169-34-3   *Mitomycins. Acta Crystallogr C 1996 Sep 15;52( Pt 9):2365-7
1,10-bisacetoxymitosene WV15  0   *Mitomycins. Anticancer Drug Des 1996 Jul;11(5):403-13
MCF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Mitomycins. Br J Cancer 1995 Jun;71(6):1315-8
3M protocol  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Mitomycins Mitoxantrone. Br J Cancer 1994 Nov;70(5):980-3
DEB-M protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Etoposide Mitomycins. Oncology (Huntingt) 1994 Mar;8(3):43-9
1a-acetylmitomycin C  1102-95-0   *Mitomycins. Pharm World Sci 1993 Jun 18;15(3):123-7
10-decarbamoylmitomycin C-N(2)-deoxyguanosine-adduct  149633-11-4   *Deoxyguanosine *Mitomycins. Biochemistry 1993 May 11;32(18):4708-18
FMB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Floxuridine Mitomycins. J Clin Oncol 1993 Feb;11(2):330-5
6-demethyl-6-formylmitomycin C  146376-40-1   *Mitomycins. J Antibiot (Tokyo) 1992 Nov;45(11):1815-7
7-(2-hydroxyethoxy)mitosane  105139-98-8 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-6-(2-hydroxyethoxy)-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))  Mitomycins. Anticancer Res 1992 May-Jun; 12(3):959-64
FuMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Mitomycins. Eur J Cancer 1992;28(2-3):390-4
MC 77  134136-38-2   *Mitomycins. Cancer Chemother Pharmacol 1992;29(4):290-6
MC 62  139112-45-1   *Mitomycins. Cancer Chemother Pharmacol 1992;29(4):290-6
7-N-(4-O-sialosylphenyl)-9-methoxymitosane methyl ester  134136-44-0   *Mitomycins. Chem Pharm Bull (Tokyo) 1991;39(2):255
7-N-(4-O-glucopyranosyl)phenyl-9-methoxymitosane  99396-19-7   *Mitomycins. Chem Pharm Bull (Tokyo) 1991;39(2):255
mitiromycin  27164-43-8   *Mitomycins. J Antibiot (Tokyo) 1991;44(3):309
10-decarbamoylmitomycin C  26909-37-5   *Mitomycins. Mutat Res 1991;254(2):143
EMV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Aminopterin/analogs & derivatives Mitomycins Vinblastine. Oncology (Williston Park) 1990;4(10):21
1a-demethylmitomycin G  74422-23-4 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-8-methylene-, (1aS-(1aalpha,8aalpha,8balpha))  *Mitomycins. J Antibiot (Tokyo) 1990;43(4):383
7-N-(N',N'-dimethylaminomethylene)aminoporfiromycin  88949-02-4 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-6-(((dimethylamino)methylene)amino)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))  *Mitomycins. Cancer Biochem Biophys 1989;10(4):289
mitomycin phosphate  124580-38-7   *Mitomycins. Cancer Res 1989;49(21):5789
FAMP protocol  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Mitomycins. Am J Clin Oncol 1989;12(4):350
KW 2149  118359-59-4   *Mitomycins.
Pharma Action Antibiotics, Antineoplastic 		Gan To Kagaku Ryoho 1988;15(11):3134
RM 49  113785-48-1 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-8-methanol, 1,1a,2,8,8a,8b-hexahydro-7-hydroxy-4,8a-dimethoxy-5-methyl-6-nitroso-, alpha-carbamate, (1aS-(1aalpha,8beta,8aalpha,8balpha))  *Mitomycins. Cancer Chemother Pharmacol 1988;22(3):246
2,7-diaminomitosene  78598-43-3   *Mitomycins. J Med Chem 1988;31(8):1579
MQF-OK-UFT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carbazilquinone Fluorouracil Tegafur Mitomycins Picibanil Uracil. Gan To Kagaku Ryoho 1988;15(7):2065
N-7-(2-(nitrophenyldithio)ethyl)mitomycin C  95056-36-3   *Mitomycins. Cancer Treat Rev 1987;14(3-4):291
FR 66973  113202-60-1 3,9-Epoxy-3H-azirino(2,3-c)(1)benzazocine-5-carboxaldehyde, 1-acetyl-7,9-bis(acetyloxy)-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,9,9a-hexahydro  *Mitomycins. Invest New Drugs 1987;5(4):339
VMMc protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitomycins Mitoxantrone Vindesine. Cancer Treat Rep 1987;71(9):845
1-hydroxy-2,7-diaminomitosene  78655-52-4   *Mitomycins. Biochemistry 1986;25(14):4077
BAFMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Doxorubicin Fluorouracil Mitomycins. Cancer Treat Rep 1986;70(4):481
MME protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Methotrexate Mitomycins. Cancer Treat Rep 1985;69(11):1241
FSM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Mitomycins Streptozocin. Cancer 1986;57(1):29
N(6)-((dimethylamino)methylene)mitomycin C  88949-01-3 Methanimidamide, N'-(8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-methoxy-5-methyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)-N,N-dimethyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))  *Mitomycins. Cancer Res 1985;45(11):5281
FOM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Mitomycins Vincristine. Wiad Lek 1985;38(11):783
mitosene  3567-35-9   *Mitomycins. J Med Chem 1985;28(7):963
mitomycin A  4055-39-4   *Mitomycins. J Med Chem 1985;28(7):963
MTF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluoxymesterone Mitomycins Tamoxifen. Cancer Treat Rep 1985;69(7-8):755
7-cysteaminomitosane  83586-81-6   *Mitomycins. Cancer Res 1984;44(12 Pt 1):5619
MV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitomycins Vinblastine. Cancer Treat Rep 1984;68(11):1325
1 alpha-(4-(N-succinimidoxycarbonyl)butyryl)mitomycin C  90906-09-5 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1-(5-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,5-dioxopentyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))  *Mitomycins. J Appl Biochem 1983;5(4-5):313
ADM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Mitolactol Mitomycins. Cancer 1984;53(9):1841
MVP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Mitomycins Vinblastine. Cancer Treat Rep 1983;67(10):943
FAMMe protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluorouracil Mitomycins Semustine. Cancer Treat Rep 1982;66(8):1613
7-amino-10-decarbamoyloxy-9-dehydro-7-demethoxymitomycin B  74148-47-3 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-1,5-dimethyl-8-methylene-, (1aS-(1aalpha,8aalpha,8balpha))  *Mitomycins. J Antibiot (Tokyo) 1981;34(9):1152
10-decarbamoyloxy-9-dehydromitomycin B  74148-44-0 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-6-methoxy-1,5-dimethyl-8-methylene-, (1aS-(1aalpha,8aalpha,8balpha))  *Mitomycins. J Antibiot (Tokyo) 1981;34(2):243
7-N-(4-hydroxyphenyl)mitomycin C  70343-57-6 Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-6-((4-hydroxyphenyl)amino)-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))  *Mitomycins. Gan 1980;71(4):560
7-methoxy-1-(N-pyrrolidino)mitosene  0   *Mitomycins. J Med Chem 21(5):493;1978
N-methylmitomycin A  18209-14-8   *Mitomycins. J Med Chem 20(6):767;1977

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